Jayan Thomas

See also: References


Select Publications from pre-2004

  • J.J. Hickman, C. Zou, D. Ofer, P.D. Harvey, M.S. Wrighton, P.E. Laibinis, C.D. Bain and G.M. Whitesides, “Combining Spontaneous Molecular Assembly with Microfabrication to Pattern Surfaces: Selective Binding of Isonitriles to Platinum Microwires and Characterization by Electrochemistry and Surface Spectroscopy,” J. Am. Chem. Soc. 111:7271 (1989).
  • P.E. Laibinis, J.J. Hickman, M.S. Wrighton and G.M. Whitesides, “Orthogonal Systems for Self-Assembled Monolayers: Alkanethiols on Gold and Alkane Carboxylic Acids on Alumina,” Science 245:845 (1989).
  • J.J. Hickman, D. Ofer, C. Zou, M.S. Wrighton, P.E. Laibinis and G.M. Whitesides, “Selective Functionalization of Gold Microstructures with Ferrocenyl Derivatives via Reaction With Thiols or Disulfides: Characterization by Electrochemistry and Auger Electron Spectroscopy,” J. Am. Chem. Soc. 113:1128 (1991).
  • J.J. Hickman, D. Ofer, P.E. Laibinis, G.M. Whitesides and M.S. Wrighton, “Molecular Self-Assembly of Two-Terminal, Voltammetric Microsensors With Internal References,” Science 252:688 (1991).
  • J.J. Hickman and M.S. Wrighton, “Face-Specific Interactions of Anionic Sulfur Donors with Oriented Crystals of (0001) CdX (X = Se, S) and Correlation with Electrochemical Properties,” J. Am. Chem. Soc. 113:4440 (1991).
  • J.J. Hickman, P.E. Laibinis, D.I. Auerbach, C. Zou, T.J. Gardner, G.M. Whitesides and M.S. Wrighton, “Toward Orthogonal Self-Assembly of Redox Active Molecules on Pt and Au: Selective Reaction of Disulfide with Au and Isonitrile with Pt,” Langmuir 8:357 (1992).
  • S.K. Bhatia, J.J. Hickman and F.S. Ligler, “A New Approach to Engineering Patterned Biomolecular Assemblies,” J. Am. Chem. Soc. 114:4432 (1992).
  • D.A. Stenger, J.H. Georger, C.S. Dulcey, J.J. Hickman, A.S. Rudolph, T.B. Nielson, S. McCort, and J.M. Calvert, “Coplanar Molecular Assemblies of Amino- and Perfluorinated Alkylsilanes: Characterization and Geometric Definition of Mammalian Cell Cultures,” J. Am. Chem. Soc. 114:8435 (1992).
  • J.J. Hickman, G.L. Bergeron, M.A. Czarnaski, and D.A. Kirkpatrick, “Surface Chemistry of TaSi2-Si Eutectic Cold Cathodes and the Effect on Vacuum Field Emission,” Appl. Phys. Lett. 61:2518 (1992).
  • D.A. Stenger, C. Pike, J.J. Hickman and C.W. Cotman, “Surface Determinants of Neuronal Survival and Growth on Self-Assembled Monolayers in Culture," Brain Res. 630:136 (1993).
  • B.J. Spargo, M.A. Testoff, T.B. Nielsen, D.A. Stenger, J.J. Hickman and A.S. Rudolph, “Adhesion, Spreading, and Differentiation of Endothelial Cells on Self-Assembled Amino- and Perfluoro-Alkylsilane Monolayers,” Proc. Nat. Acad. Sci. USA 91:11070 (1994).
  • J.J. Hickman and D.A. Stenger, “Interactions of Cultured Neurons with Defined Surfaces,” in: Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, Eds.), 1st edition. San Diego: Academic Press, Inc. 51 (1994).
  • D.A. Stenger and J.J. Hickman, “Lithographic Definition of Neuronal Microcircuits,” in: Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, Eds.), 1st edition. San Diego: Academic Press, Inc. 77 (1994).
  • A.E. Schaffner, J.L. Barker, D.A. Stenger and J.J. Hickman, “Investigation of the Factors Necessary for Growth of Hippocampal Neurons in a Defined System,” J. Neuroscience Methods 62:111 (1995).
  • D.R. Jung, D.S. Cuttino, J.J. Pancrazio, P. Manos, T. Custer, R.S. Sathanoori, L.E. Aloi, M.G. Coulombe, M.A. Czarnaski, D.A. Borkholder, G.T. Kovacs, P. Bey, D.A. Stenger and J.J. Hickman, “Cell-Based Sensor Microelectrode Array Characterized by Imaging XPS, SEM, Impedance Spectroscopy, and Cellular Recordings,” J. Vac. Sci. Tech. A 16:1183 (1998).
  • D.A. Stenger, J.J. Hickman, K.E. Bateman, M.S. Ravenscroft, W. Ma, J.J. Pancrazio, K.M. Shaffer, A.E. Schaffner, D.H. Cribbs and C.W. Cotman, “Microlithographic Definition of Axonal/Dendritic Polarity in Cultured Hippocampal Neurons,” J. Neuroscience Methods 82:167 (1998).
  • M.S. Ravenscroft, K.E. Bateman, K.M. Shaffer, H.M. Schessler, D.R. Jung, T.W. Schneider, C.B. Montgomery, T.L. Custer, A.E. Schaffner, Q.Y. Liu, Y.X. Li, J.L. Barker and J.J. Hickman, “Developmental Neurobiology Implications from Fabrication and Analysis of Hippocampal Neuronal Networks on Patterned Silane-Modified Surfaces,” J. Amer. Chem. Soc. 120:12169 (1998).
  • K. Lenghaus, J. Dale, C. Henderson, D. Henry, E. Loghin and J.J. Hickman, “Enzymes as Ultra-Sensitive Probes for Adsorption in Flow Systems,” Langmuir 19:5971 (2003).


  • T. Xu, S. Petridou, E. Lee, E. Roth, N. Vyavahare, J.J. Hickman and T. Boland, “Construction of High-Density Bacterial Colony Arrays and Patterns by the Ink-jet Method,” Journal of Biotechnology & Bioengineering 85:29 (2004).
  • E. A. Roth, T. Xu, M. Das, C. Gregory, J.J. Hickman and T. Boland, “Inkjet Printing for High Throughput Cell Patterning,” Biomaterials 25(17): 3707-3715 (2004).
  • J.K. Evju, P.B. Howell, L.E. Locascio, M.J. Tarlov and J.J. Hickman, “Atmospheric Pressure Microplasmas for Modifying Sealed Microfluidic Devices,” Applied Physics Letters 84(10):1668-1670 (2004).
  • B. Sweryda-Krawiec, H. Devaraj, G. Jacob, and J.J. Hickman, “A New Interpretation of Serum Albumin Surface Passivation,” Langmuir 20(6):2054-2056 (2004).
  • M. Das, P Molnar, C. Gregory, L. Riedel and J.J. Hickman, “Long-term Culture Of Embyonic Rat Cardiomyocytes on an Organosilane Surface in a Serum Free Medium,” Biomaterials 25(25):5643-5647 (2004).
  • F. Jin, J.J. Hickman, K. Lenghaus and R. Marcus, “Total Protein Determinations by Particle Beam/Hollow Cathode Optical Emission Spectroscopy (PB/HC-OES)System II: Improved Sensitivity Through Use of Silica Micro-particles as Carrier Agents for Enhanced Particle Transport,” Journal of Analytical Atomic Spectrometry 19(9):1199-1205 (2004).
  • F. Jin, J.J. Hickman, K. Lenghaus, R. Marcus, “Total Protein Determinations by Particle Beam/Hollow Cathode Optical Emission Spectroscopy (PB/HC-OES) System III: Investigation of Carrier Salts for Enhanced Particle Transport,” Anal Bioanal Chem. 380 (2):204-211 (2004).
  • J. Jenkins, B. Prabhakarpandian., K. Lenghaus, J.J. Hickman, S. Sundaram, “Fluidics Resolved Analysis of Protein Adsorption in a Biomicrofluidic System,” Analytical Biochem 331:207-215 (2004).


  • T. Xu, J. Jin, C. Gregory, J.J. Hickman and T. Boland, “Inkjet Printing of Viable Mammalian Cells,” Biomaterials 26(1):93-99 (2005).
  • A. Behal, D.M. Dawson, P. Molnar and J.J. Hickman, “The stretch reflex arc: simulation, control and identification” (http://pegasus.cc.ucf.edu/~pmolnar/bio-paper_journal2.pdf) (2005)
  • M. Das, N. Bhargava, C. Gregory, L. Riedel, P. Molnar and J.J. Hickman, “Adult Rat Spinal Cord Culture on an Organosilane Surface in a Novel Serum-Free Medium” In Vitro Cell Dev Biol- Animal 41:343-348 (2005).
  • J.J. Hickman, “Building Minimalistic Hybrid Neuroelectric Devices,” in Toward Replacement Parts for the Brain: Implantable Biomimetic Electronics as Neural Prosthetic (T.W. Berger and D.L. Glanzman Eds.), 1st edition. Cambridge, MA: MIT Press (2005).
  • J.J. Hickman, P. Molnar, M. Hirsch-Kuchma, J.W. Rumsey, K. Wilson “Biosurface Engineering, Cell Patterning,” in Wiley Encyclopedia of Medical Devices and Instrumentation (John G. Webster), 2nd edition. Hoboken, NJ: John Wiley & Sons, Inc. (2005)


  • A. Natarajan, P. Molnar, K. Sieverdes, K. Jamshidi and J.J. Hickman, “Multielectrode Recordings of Cardiac Action Potentials as a High Throughput Method to Evaluate Pesticide Toxicity,” Toxicology In Vitro 20(3):375-381 (2006).
  • D. K Mohan, P. Molnar and J.J. Hickman. “Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells,” Biosensors & Bioelectronics 21:1804-1811 (2006).
  • M. Das, C. Gregory, K. Wilson, P. Molnar, L. Riedel and J.J. Hickman, “A Defined System to Allow Skeletal Muscle Differentiation and Subsequent Integration with Silicon Microstructures,” Biomaterials 27(24):4374-4380 (2006).
  • S. Krishnamoorthy, J. Feng, A. Henry, L. Locascio, J.J. Hickman and S. Sundaram, “Simulation and Experimental Characterization of Electroosmotic Flow in Surface Modified Channels,” Microfluidics and Nanofluidics 2:345-355 (2006).
  • D. Henry, K. Lenghaus, K.A. Wilson, M. Hirsch-Kuchma, J. Jenkins, S. Sundaram and J.J. Hickman, “Submonolayer Measurements of Adsorbed Proteins In Microfluidic Channels,” in Bionanotechnology: Proteins to Nanodevices (V. Renugopalakrishnan, Randy V Lewis, Pawan K Dhar), Dordrecht, The Netherlands: Springer Press, (2006).


  • M. Das, S. Patil, N. Bhargava, J.F. Kang, L. Riedel, S. Seal and J.J. Hickman, “Auto-catalytic Ceria Nanoparticles Offer Neuroprotection to Adult Rat Spinal Cord Neurons,” Biomaterials 28:1918-1925 (2007).
  • P. Molnar, W. Wang, A. Natarajan, J.W. Rumsey and J.J. Hickman, “Photolithographic Patterning of C2C12 Myotubes using Vitronectin as Growth Substrate in Serum-Free Medium,” Biotechnology Progress 23(1): 265-268 (2007).
  • M. Das, J.W. Rumsey, C.A. Gregory, N. Bhargava, J.F. Kang, P. Molnar, L. Riedel, J.J. Hickman, “Embryonic Motor Neuron-Skeletal Muscle Co-culture in a Defined System,” Neuroscience 146:481-488 (2007).
  • K. Wilson, P. Molnar and J.J. Hickman, “Integration of Functional Myotubes with a Bio-MEMS Device for Non-Invasive Interrogation,” Lab-on-a-Chip 7:920-922 (2007).
  • M. Das, K. Wilson, P. Molnar and J.J. Hickman, “Differentiation of Skeletal Muscle and Integration of Myotubes with Silicon Microstructures using Serum-Free Medium and a Synthetic Silane Substrate,” Nature Protocols 2(7):1795-1801 (2007).
  • P. Molnar, J.J. Hickman, “Modeling of action potential generation in NG108-15 cells,” Methods Mol. Biol. 403:175-84 (2007).
  • P. Molnar P, JF. Kang, N. Bhargava, M. Das and J.J. Hickman, “Synaptic connectivity in engineered neuronal networks.” Methods Mol. Biol. 403:165-73 (2007).
  • P. Molnar, J.F. Kang, N. Bhargava, M. Das and J.J. Hickman, “Synaptic Connectivity in Engineered Neuronal Networks,” in Patch Clamp Methods and Protocols Humana Press Methods in Molecular Biology Series, (July 2007).
  • P. Molnar and J.J. Hickman, “Modeling of Action Potential Generation inNG108-15 Cells,” in Patch Clamp Methods and Protocols Humana Press Methods in Molecular Biology Series, (July 2007).


  • M. Das, N. Bhargava, A. Bhalkikar, J. F. Kang and J. J. Hickman, “Temporal Neurotransmitter Conditioning Restores the Functional Activity of Adult Spinal-Cord Neurons in Long-Term Culture,” Experimental Neurology 209:171-180 (2008).
  • J.W. Rumsey, M. Das, J.F. Kang, R. Wagner, P. Molnar and J.J Hickman, “Tissue Engineering Intrafusal Fibers: Dose and Time Dependent Differentiation of Nuclear Bag Fibers in a Defined In Vitro System using Neuregulin 1-β-1,” Biomaterials 29:994-1104 (2008).
  • J. Liu, J.W. Rumsey, P. Molnar, M. Das, C. Gregory, L. Riedel and J.J. Hickman, “Electrophysiological and Immunocytochemical Characterization of DRG Neurons on an Organosilane Surface in Serum Free Medium,” In Vitro Cellular & Developmental Biology 44:162-168 (2008).
  • A. Natarajan, C.J. Chun, J.J. Hickman and P. Molnar, "Growth and Electrophysiological Properties of Rat Embryonic Cardiomyocytes on Hydroxyl- and Carboxyl-Modified Surfaces,” Journal of Biomaterials Science: Polymer Edition 19(10):1319-1331 (2008).
  • V. Thakore, A. Behal, P. Molnar, D.C. Leistritz, and J.J. Hickman, “Nanoscale Nonlinear Dynamic Characterization of the Neuron-Electrode Junction,” J. Comput. Theor. Nanosci. 5(11):2164-2169 (2008).
  • J. Rolland, K-S. Lee, A. Mahmood, L. Fluck, J. Duarte, I. Kaya, A. Santhanam, P. Meemon, S. Murali, O. Ilegbusi, P. Kupelian, A.M. Kachurin, W.L. Warren, P. Molnar, J.J. Hickman and P.K. Kolattukudy, Eds J.D. Westwood, R.S. Haluck, H.M.Hoffman, G.T. Mogel, R. Phillips, R.A. Robb and K.G. Vosburgh, “Collaborative Engineering: 3-D Optical Imaging and Gas Exchange Simulation of In-Vitro Alveolar Constructs,” in Studies in Health Technolology Informatics 132:426-432 (2008).
  • Rolland, J. P., K. S. Lee, A. Mahmood, L. Fluck, J. Duarte, I. Kaya, A. Santhanam, P. Meemon, S. Murali, O. Ilegbusi, P. Kupelian, W. L. Warren, P. Molnar, J. J. Hickman and P. E. Kolattukudy. Collaborative Engineering: 3-D Optical Imaging and Gas Exchange Simulation of In-Vitro Alveolar Constructs. Medicine Meets Virtual Reality 16 - parallel, combinatorial, convergent: NextMed by Design. J. D. Westwood, R. S. Haluck, H. M. Hoffmanet al. 132. (2008).
  • M. Ramalingam, P, Molnar and J.J. Hickman, “Nano-Surface Patterning Techniques for Cell Studies,” Encyclopedia of Nanoscience and Nanotechnology (ENN) American Scientific Publishers, Valencia, California, (2008).
  • M. Ramalingam, S. Ramakrishna and J.J. Hickman, “Cell Responsive Nano-fibrous Materials for Tissue Engineering,” in Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publishers, Ed. Hari Singh Nalwa, Valencia, California, (2008).


  • K. Varghese, M. Das, N. Bhargava, P. Molnar, M.S. Kind and J.J. Hickman, “Regeneration and Characterization of Adult Mouse Hippocampal Neurons in a Defined In Vitro System,” Journal of neuroscience methods 177:51-59 (2009).
  • M. Ramalingam, P. Molnar, K. P. Rao and J. J. Hickman, “Biomaterial Surface Patterning Utilizing Self Assembled Monolayers to Control Neuronal Cell Behavior,” Int. Journal of Biomedical Engineering and Technology, Review 2(2):104-134 (2009).
  • J.W. Rumsey, M. Das, M. Stancescu, M. Bott, C. Fernandez-Valle and J.J. Hickman, “Node of Ranvier Formation on Motoneurons In Vitro,” Biomaterials 30:3567-3572 (2009).
  • T. Xu, P, Molnar, C. Gregory, M. Das, T. Boland and J.J. Hickman, “Electrophysiological Characterization of Embryonic Hippocampal Neurons Cultured in 3D Collagen Hydrogel,” Biomaterials 30:4377-4383 (2009).
  • M. Das, J. W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman, “Skeletal Muscle Tissue Engineering: An Improved Model Promoting Long Term Survival of Myotubes, Structural Development of E-C Coupling Apparatus and Neonatal Myosin Heavy Chain (MHC) Expression,” Biomaterials 30:5392-5402 (2009).
  • M. Das, J.W. Rumsey, N. Bhargava, C. Gregory, L. Riedel, J.F. Kang, J.J. Hickman, “Developing a Novel Serum-Free Cell Culture Model of Skeletal Muscle Differentiation by Systematically Studying the Role of Different Growth Factors in Myotube Formation,” In Vitro Cell Dev Biol Animal 45:378-387 (2009).
  • N. Akanda, M. Stancescu, P. Molnar and J.J. Hickman, “Analysis of Toxin Induced Changes in Action Potential Shape for Drug Development,” Journal of Biomolecular Screening 14(10):1228-1235 (2009).
  • N. Bhargava, M. Das, A. S. Karakoti, S. Patil, J.F. Kang, M. Stancescu, M. S. Kindy, S. Seal and J.J. Hickman, “Regeneration of Adult Mice Motoneurons Utilizing a Defined System and Anti-oxidant Nanoparticles,” Journal of Nanoneuroscience 1(2):130-143 (2009).
  • D.G. Taylor, A. Natarajan, B. Moscato, P. Molnar, J.J. Hickman, S.N. Ebert, “Adrenergic Deficiency Leads to Slowed Ventricular Conduction and Increased Arrhythmias in Embryonic Mouse Hearts,” Circulation 120(18):S616 (2009).


  • M.S. Ravenscroft-Chang, J. Stohlman, P. Molnar, A. Natarajan, H.E. Canavan, M. Teliska, M. Stancescu, V. Krauthamer and J.J. Hickman, “Altered Calcium Dynamics in Cardiac Cells Grown on Silane-Modified Surfaces,” Biomaterials 31:602-607 (2010).
  • C.M. Smith, T.D. Roy, A. Bhalkikar, B. Li, J.J. Hickman and K.H. Church, “Engineering a Titanium and Polycaprolactone Construct for a Biocompatible Interface Between the Body and Artificial Limb,” Tissue Engineering Part A 16(2):717-724 (2010). X.F. Guo, K. Johe, P. Molnar, H. Davis, J.J. Hickman, “Characterization of a Human Spinal Cord Stem Cell Line and Its Induction to Motoneurons,” Tissue Engineering and Regenerative Medicine 4:181-193 (2010).
  • K. Varghese, P. Molnar, M. Das, N. Bhargava, S. Lambert, M.S. Kindy and J.J. Hickman, “A New Target for Amyloid Beta Toxicity Validated by Standard and High-throughput Electrophysiology,” PLoS One 5(1): e8643. doi:10.1371/journal.pone.0008643 (2010).
  • M. Das, J.W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman, “A Defined Long-Term In Vitro Tissue Engineered Model of Neuromuscular Junctions,” Biomaterials 31:4880-4888 (2010).
  • K. Wilson, M. Das, K.J. Wahl, R.J. Colton and J.J. Hickman, “Measurement of Contractile Stress Generated by Cultured Muscle on Silicon Cantilevers,” PLoS One 5(6): e11042. doi: 10.1371/journal.pone.0011042 (2010).
  • D. Edwards, M. Das, P. Molnar and J.J. Hickman, “Addition of Glutamate to Serum Free Culture Promotes Recovery of Electrical Activity in Adult Hippocampal Neurons In Vitro,” J Neuroscience Methods 190:155-163 (2010).
  • L. Chi, J. Yu, H. Zhu, X. Li, S. Zhu, Z. Li, L.C. Pettigrew, D. Grass, J.J. Hickman, M.S. Kindy, “Dual Neuronal Response to Tumor Necrosis Factor-alpha Following Spinal Cord Injury,” Neural Regeneration Research 5(12):917-926 (2010).
  • J.W. Rumsey, M. Das, A. Bhalkikar, M. Stancecsu and J.J. Hickman, “Tissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc: Sensory Neuron Innervation of Intrafusal Muscle Fibers,” Biomaterials 31:8218-8227 (2010).
  • N. Bhargava, M. Das, D. Edwards, M. Stancescu, J.-F. Kang and J.J. Hickman, “Coexpression of Glutamate Vesicular Transporter (VGLUT1) and Choline Acetyltransferase (ChAT) Proteins in Embryonic Rat Hippocampal Neurons in Culture,” In Vitro Cell Dev Animal 46:685-692 (2010).
  • C. Wang, L. Ma, M. Hossain, H. Wang, S. Zou, J.J. Hickman, M. Su, “Direct visualization of molecular scale chemical adsorptions on solids using plasmonic nanoparticle arrays,” Sensors and Actuators, B:Chemical 150(2):667-672 (2010).
  • C. Wang, M. Hossain, L. Ma, Z. Ma, J.J. Hickman, M. Su, “Highly Sensitive Thermal Detection of Thrombin Using Aptamer-Functionalized Phase Change Nanoparticles,” Biosensors & Bioelectronics 26(2):437-43 (2010).
  • J.C. Henderson, M. Yacopucci, C.J. Chun, K. Lenghaus and J.J. Hickman, “Investigation of the Behavior of Serum Plasma in a Microfluidics System,” JVST B 28(5):1066-1069 (2010).
  • X. Guo, M. Das, J. Rumsey, M. Gonzalez, M. Stancescu and J.J. Hickman, “Neuromuscular Junction Formation between Human Stem Cell derived Motoneurons and Rat Skeletal Muscle in a Defined System,” Tissue Engineering, Part C 16(6):1347-1355 (2010).
  • M. Ramalingam, S.S. Liao, S. Ramakrishna, P. Molnar, Z.M. Huang, M. Kotaki, K. Panduranga Rao and J.J. Hickman, “Skeletal Regeneration Nanobiomaterials,” in Biomaterials for Bone, Regenerative Medicine, TTP Publishers, Swiss/USA, (2010).


  • K. Wilson, M. Stancescu, M. Das, J.W. Rumsey and J.J. Hickman, “Direct Patterning of Coplanar Peg Alkylsilane Monolayers by Deep –Ultraviolet Photolithograpy as a General Method for Long-Term Cell Patterning and Culture,” JVST B 29(2):021020 (2011).
  • A. Natarajan, M. Stancescu, V. Dhir, C. Armstrong, F. Sommerhage, J.J. Hickman and P. Molnar, “Patterned Cardiomyocytes on Microelectrode Arrays as a Device for Studying Cardiac Electrophysiology and Drug Effects,” Biomaterials 32(18):4267-4274 (2011).
  • X. Guo, M. Gonzalez, M. Stancescu, H. Vandenburgh, J.J. Hickman, “Neuromuscular Junction Formation between Human Stem cell-derived Motoneurons and Human Skeletal Muscle in a Defined System,” Biomaterials 32:9602-9611 (2011).


  • K.A. Wilson, C. A. Finch, P. Anderson, F. Vollmer, and J.J. Hickman, “Whispering Gallery Mode Biosensor Quantification of Fibronectin Adsorption Kinetics onto Alkylsilane Monolayers and Interpretation of Resultant Cellular Response” Biomaterials 33:225-236 (2012).
  • H. Davis, X. Guo, S. Lambert, M. Stancescu and J.J. Hickman, “Small Molecule Induction of Human Umbilical Stem Cells into MBP-Positive Oligodendrocytes in a Defined Three-Dimensional Environment,” ACS Chemical Neuroscience 3:31-39 (2012).
  • X. Guo, J.E. Ayala1, M. Gonzalez, M. Stancescu, S. Lambert, J.J. Hickman, “Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons,” Biomaterials 33(23):5723-5731 (2012).
  • C. Long, C. Finch, M. Esch, W. Anderson, M. Shuler and J.J. Hickman, “Design Optimization of Liquid-Phase Flow Patterns for Microfabricated Lung On A Chip,” Annals of Biomedical Engineering 40(6):1255-1267 (2012).
  • H. Davis, M. Gonzalez, N. Bhargava, M. Stancescu, J.J. Hickman, and S. Lambert, “Rat Cortical Oligodendrocyte–Embryonic Motoneuron Co-culture: An in vitro Axon-Oligodendrocyte Interaction Model,” Journal of Biomaterials & Tissue Engineering 2(3):206-214 (2012).
  • V. Thakore, P. Molnar and J.J. Hickman, “An Optimization Based Study of Equivalent Circuit Models for Representing Recordings at the Neuron-Electrode Interface,” IEEE Transactions on Biomedical Engineering 59(8):2338-2347 (2012).
  • C. Wang, J. Reed, L. Ma, Y. Qiao, Y. Luo, S. Zou, J.J. Hickman and M. Su, “Biomimic Light Trapping Silicon Nanowire Arrays for Laser Desorption/Ionization of peptides,” Journal of Physical Chemistry C 116(29):15415-15420 (2012).
  • C.N. Baker, D.G. Taylor, K. Osuala, A. Natarajan, P. Molnar, J.J. Hickman, S. Alam, B. Moscato, D. Weinshenker, and S.N. Ebert, “Adrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heart,” Biochemical and Biophysical Research Communications 423(3):536-541 (2012).
  • X. Guo, J.J. Hickman. “Treatment of ALS utilizing a stem cell strategy” in Motor Neuron Diseases: Causes, Classification and Treatments Eds. B.J. Turner, J.B. Atkin, Nova Science Publishers, Hauppauge, New York. pp.115-136 (2012).


  • S.A. Khan, V. Thakore, A. Behal, L. Bölöni and J.J. Hickman, “Comparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction,” Journal of Computational and Theoretical Nanoscience, 10(3):573-580 (2013).
  • A. Natarajan, T. DeMarse, P. Molnar, J.J. Hickman, “Engineered In Vitro Feed-Forward Networks,” Journal of Biotechnology and Biomaterials 3(1):153 (2013).
  • X. Guo, S. Spradling, M. Stancescu, S. Lambert, J.J. Hickman, “Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1,” Biomaterials 34:4418-4427 (2013).
  • J.H. Sung, M.B. Esch, J.-M. Prot, C.J. Long, A. Smith, J.J. Hickman and M.L. Shuler, “Microfabricated mammalian organ systems and their integration into models of whole animals and humans,” Lab on a Chip 13:1201-1212 (2013).
  • C. Finch, T. Clarke, and J.J. Hickman, “A Continuum Hard-Sphere Model of Protein Adsorption,” Journal of Computational Physics, 244:212-222 (2013).
  • J.W. Rumsey, C. McAleer, M. Das, A. Bhalkikar, K. Wilson, M. Stancescu, S. Lambert, J.J. Hickman, “Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system,” In Vitro Cell Dev Biol Anim, 49:608-618 (2013).
  • K.L. Pirozzi C.J. Long, C.W. McAleer, A.S.T. Smith and J.J. Hickman, “Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an Atomic Force Microscopy-based bio- Microelectromechanical systems device,” Applied Physics Letters, 103:083108 (2013).
  • D. Edwards, M. Stancescu, P. Molnar and J.J. Hickman, “Two cell networks of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system,” ACS Chemical Neuroscience 4:1174-1182 (2013) DOI: 10.1021/cn300206k
  • A.S.T. Smith, C.J. Long, Kristen Pirozzi and J.J. Hickman, “Development of a functional system for high-content screening of neuromuscular junctions,” Technology, 1(1):37-48 (2013).


  • X. Guo, K. Greene, N. Akanda, A.S.T. Smith, M. Stancescu, S. Lambert, H. Vandenburgh, and J.J. Hickman, “In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System,” Biomaterials Science 2:131-138 (2014).
  • A.S.T. Smith, C.J. Long, B.J. Berry, C. McAleer, M. Stancescu, P. Molnar, P.G. Miller, M.B. Esch, J.-M. Prot, J.J. Hickman and M.L. Shuler, “Microphysiological systems and low cost microfluidic platform with analytics,” Stem Cell Research and Therapy in press (2014).
  • Esch, M.B., Smith, A., Prot, J.M., Oleaga, C., Hickman, J., and Shuler, M.L. 2014. How Multi-Organ Microdevices Can Help Foster Drug Development. Advanced Drug Delivery Reviews, 69-70 (2014) 158-169.
  • Sung, J.H., Srinivasan, B., Esch, M.B., McLamb, W.T., Bernabini, C., Shuler, M.L., and J.J. Hickman. 2014. Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure. Experimental Biology and Medicine. 239:1225-1239.
  • A.S.T. Smith, C.J. Long, C. McAleer, N. Bobbitt, B. Srinivasan and J.J. Hickman, “Utilization of microscale silicon cantilevers to assess cellular contractile function in vitro,” accepted to JoVE (2014).
  • M. Ramalingam, P, Molnar and J.J. Hickman, “Surface Patterning of Biomaterials to Control Cell Behavior,” Encyclopedia of Nanoscience and Nanotechnology (ENN) American Scientific Publishers, Valencia, California, in press.
  • Shuler, M.L. and J.J. Hickman. 2014. Toward in vitro models of brain structure and function. PNAS. 111(38): 13682-13683.
  • 2015

  • Srinivasan, B., Kolli, A.R., Esch, M.B., Abaci, H.E., Shuler, M.L., and J.J. Hickman. 2015. TEER measurement techniques for in vitro barrier model systems. J Lab Automation. 20:107-126
  • C.W. McAleer, A.S.T. Smith, S. Najjar, K. Pirozzi, C.J. Long and J.J. Hickman, “Mechanistic Investigation of Adult Myotube Response to Exercise and Drug Treatment in Vitro Using a Multiplexed Functional Assay System,” J Appl Physiol 117(11):1398-1405 (2015).
  • B. Srinivasan, A.R. Kolli, M.B. Esch, H.E. Abaci, M.L. Shuler and J.J. Hickman, “TEER Measurement Techniques for Organs-On-Chips Systems,” JALA 20(2):107-126 (2015).
  • C. McAleer, J.W. Rumsey, M. Stancescu and J.J. Hickman, “Functional Myotube Formation from Adult Rat Satellite Cells in a Defined Serum-Free System,” Biotechnology Progress 31(4):997-1003 (2015).
  • M. Stancescu, P. Molnar, C. McAleer, W. McLamb, C. Long, C. Oleaga, J.-M. Prot and J.J. Hickman, “In Vitro Model of Whole Heart Function,” Biomaterials 60:20-30 (2015).
  • B.J. Berry, N. Akanda, A.S.T. Smith, C.J. Long, M.T. Schnepper, X. Guo and J.J. Hickman, “Functional Characterization of Human Induced Pluripotent Stem Cell Neurons in Different Defined Culture Systems,” Biotechnology Progress in press (2015).
  • 2016

  • C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M.B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M.L. Shuler & J.J. Hickman “Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs” Scientific Reports (6):20030 (2016)
  • 2017

  • Xiufang Guo, Alisha Colon, Nesar Akanda, Severo Spradling, Maria Stancescu, Candace Martin, James J. Hickman, “Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers,” Biomaterials 122:179-187 (2017). http://dx.doi.org/10.1016/j.biomaterials.2017.01.005

Hybrid Systems Lab, NanoScience Technology Center at the University of Central Florida
E-mail: Cathleen.Wolf@ucf.edu  •  Phone: 407.882.1121  •  Fax: 407.882.2819
Nathaniel Bobbitt Website Design