Quantum Dot Nanotechnology
Activatable Quantum Dot (Qdot) Probes for Bioimaging and Sensing Applications
In drug discovery research, quantification of the amount of anticancer drug delivered to live cancer cells is critical but highly challenging. More specifically this is of particular interest for evaluating therapeutic efficacy of any new drugs that enters into pre-clinical trials. We have successfully developed novel Qdot based activatable ("OFF"/"ON") probes and demonstrated successfully their efficacy for detecting intra-cellular drug release event. We are currently evaluating efficacy of the probes for quantifying the amount of drug released intra-cellularly via optical spectroscopy and microscopy. By design, these probes are imageable by MRI, X-Ray CT and Optical Tomography.
- Mitra, R. N.; Doshi, M.; Zhang, X. L.; Tyus, J. C.; Bengtsson, N.; Fletcher, S.; Page, B. D. G.; Turkson, J.; Gesquiere, A. J.; Gunning, P. T.; Walter, G. A.; Santra, S. , "An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery." Biomaterials 2012, 33 (5), 1500-1508.
- Malhotra A., Zhang X., Turkson J. and Santra, S. , "Buffer stable chitosan-polyglutamic acid hybrid nanoparticles for biomedical applications", Macromolecular Bioscience, 2013 (published online); DOI: 10.1002/mabi.201200425.
- US patent # 7,807,265
- US patent # 8,128,908