{"id":62,"date":"2023-03-26T16:52:59","date_gmt":"2023-03-26T20:52:59","guid":{"rendered":"https:\/\/nanoscience.ucf.edu\/hickman\/?page_id=62"},"modified":"2025-11-03T12:41:14","modified_gmt":"2025-11-03T17:41:14","slug":"publications","status":"publish","type":"page","link":"https:\/\/nanoscience.ucf.edu\/hickman\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Jump to:<\/em> 2025<\/a> 2024<\/a> 2023<\/a> 2022<\/a> 2021<\/a> 2020<\/a> 2019<\/a> 2018<\/a> 2017<\/a> 2016<\/a> 2015<\/a> 2014<\/a> 2013<\/a> 2012<\/a> 2011<\/a> 2010<\/a> 2009<\/a> 2008<\/a> 2007<\/a> 2006<\/a> 2005<\/a> 2004<\/a> Pre-2004<\/a><\/p>\n\n\n\n

See also:<\/em> References<\/a><\/p>\n\n\n\n

2025<\/h2>\n\n\n\n

Autar K, Guo X, Powell H, Patel A, Malik M, Grillo M, Akanda N, Narasimhan NS, Bogen W, Long C, Ammar RM, Hickman J. Developing a functional non-animal CNS stress model utilizing long-term potentiation with human iPSC-cortical neurons to evaluate therapeutics. Biomed Pharmacother. 2025 Sep 27;192:118556. doi: 10.1016\/j.biopha.2025.118556. [Epub ahead of print] PubMed PMID: 41016149.<\/p>\n\n\n\n

Weber T, Malakpour-Permlid A, Chary A, D’Alessandro V, Haut L, Seufert S, Wenzel EV, Hickman J, Bieback K, Wiest J, Dirks WG, Coecke S, Oredsson S. Fetal bovine serum: how to leave it behind in the pursuit of more reliable science. Front Toxicol. 2025;7:1612903. doi: 10.3389\/ftox.2025.1612903. eCollection 2025. Review. PubMed PMID: 40861932; PubMed Central PMCID: PMC12371577.<\/p>\n\n\n\n

Rupar MJ, Hanson HM, Botlick BL, Sriram N, Rogers S, Zuniga J, Liu Z, Trimmer SJ, Ciurca JM, Long CJ, McAleer CW, Schmidt S, Favuzza P, Lowe P, Gobeau N, Hickman JJ. Translation of a Human-Based Malaria-on-a-Chip Phenotypic Disease Model for In Vivo Applications. Adv Sci (Weinh). 2025 Oct;12(38):e05206. doi: 10.1002\/advs.202505206. Epub 2025 Jul 21. PubMed PMID: 40686419; PubMed Central PMCID: PMC12520463.<\/p>\n\n\n\n

Malik M, Steele SA, Mitra D, Long CJ, Hickman JJ. Trans-epithelial\/endothelial electrical resistance (TEER): Current state of integrated TEER measurements in organ-on-a-chip devices. Curr Opin Biomed Eng. 2025 Jun;34. doi: 10.1016\/j.cobme.2025.100588. Epub 2025 Mar 19. PubMed PMID: 40276329; PubMed Central PMCID: PMC12017418.<\/p>\n\n\n\n

Smieszek S, Przychodzen B, Tyner C, Johnson C, Bai H, Kwon JM, Hagan DW, Niccum C, Brighton R, Hawkins K, Aiken R, Nawaz A, Guo X, Hickman J, Polymeropoulos CM, Birznieks G, Polymeropoulos MH. Potential ASO-based personalized treatment for Charcot-Marie-Tooth disease type 2S. Mol Ther Nucleic Acids. 2025 Mar 11;36(1):102479. doi: 10.1016\/j.omtn.2025.102479. eCollection 2025 Mar 11. PubMed PMID: 40060931; PubMed Central PMCID: PMC11889396.<\/p>\n\n\n\n

Marx U, Beken S, Chen Z, Dehne EM, Doherty A, Ewart L, Fitzpatrick SC, Griffith LG, Gu Z, Hartung T, Hickman J, Ingber DE, Ishida S, Jeong J, Leist M, Levin L, Mendrick DL, Pallocca G, Platz S, Raschke M, Smirnova L, Tagle DA, Trapecar M, van Balkom BWM, van den Eijnden-van Raaij J, van der Meer A, Roth A. Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare. ALTEX. 2025;42(2):204-223. doi: 10.14573\/altex.2410112. Epub 2025 Jan 17. PubMed PMID: 39827406.<\/p>\n\n\n\n

2024<\/h2>\n\n\n\n

Patel A, Poddar S, Nierenberg D, Lang S, Wang H, Pires DeMello CP, Gamarra J, Colon A, Kennedy P, Roles J, Klion J, Bogen W, Long C, Guo X, Tighe P, Schmidt S, Shuler ML, Hickman JJ. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Curr Res Toxicol. 2025;8:100209. doi: 10.1016\/j.crtox.2024.100209. eCollection 2025. PubMed PMID: 39839141; PubMed Central PMCID: PMC11745978.<\/p>\n\n\n\n

Caneus J, Autar K, Akanda N, Grillo M, Long CJ, Jackson M, Lindquist S, Guo X, Morgan D, Hickman JJ. Validation of a functional human AD model with four AD therapeutics utilizing patterned ipsc-derived cortical neurons integrated with microelectrode arrays. Sci Rep. 2024 Oct 22;14(1):24875. doi: 10.1038\/s41598-024-73869-9. PubMed PMID: 39438515; PubMed Central PMCID: PMC11496884.<\/p>\n\n\n\n

Patel A, Williams M, Hawkins K, Gallo L, Grillo M, Akanda N, Guo X, Lambert S, Hickman JJ. Establishment of a Serum-Free Human iPSC-Derived Model of Peripheral Myelination. ACS Biomater Sci Eng. 2024 Nov 11;10(11):7132-7143. doi: 10.1021\/acsbiomaterials.4c01431. Epub 2024 Oct 22. PubMed PMID: 39437333; PubMed Central PMCID: PMC11558563.<\/p>\n\n\n\n

Gallo LH, Akanda N, Autar K, Patel A, Cox I, Powell HA, Grillo M, Barakat N, Morgan D, Guo X, Hickman JJ. A functional aged human iPSC-cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics. Alzheimers Dement. 2024 Sep;20(9):5940-5960. doi: 10.1002\/alz.14044. Epub 2024 Jul 30. PubMed PMID: 39077965; PubMed Central PMCID: PMC11633364.<\/p>\n\n\n\n

Rupar MJ, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman JJ. Modelling the innate immune system in microphysiological systems. Lab Chip. 2024 Jul 23;24(15):3604-3625. doi: 10.1039\/d3lc00812f. Review. PubMed PMID: 38957150; PubMed Central PMCID: PMC11264333.<\/p>\n\n\n\n

Caneus J, Autar K, Akanda N, Grillo M, Long C, Jackson M, Lindquist S, Guo X, Morgan D, Hickman JJ. Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays. Res Sq. 2024 May 20;. doi: 10.21203\/rs.3.rs-4313679\/v1. PubMed PMID: 38826367; PubMed Central PMCID: PMC11142300.<\/p>\n\n\n\n

Reyes DR, Esch MB, Ewart L, Nasiri R, Herland A, Sung K, Piergiovanni M, Lucchesi C, Shoemaker JT, Vukasinovic J, Nakae H, Hickman J, Pant K, Taylor A, Heinz N, Ashammakhi N. From animal testing to in vitro systems: advancing standardization in microphysiological systems. Lab Chip. 2024 Feb 27;24(5):1076-1087. doi: 10.1039\/d3lc00994g. Review. PubMed PMID: 38372151.<\/p>\n\n\n\n

Patel A, Williams M, Hawkins K, Gallo L, Grillo M, Akanda N, Guo X, Lambert S, Hickman JJ.<\/strong> Establishment of a Serum-Free Human iPSC-Derived Model of Peripheral Myelination. ACS Biomater Sci Eng. 2024 <\/p>\n\n\n\n

Caneus J, Autar K, Akanda N, Grillo M, Long CJ, Jackson M, Lindquist S, Guo X, Morgan D, Hickman JJ. <\/strong>Validation of a functional human AD model with four AD therapeutics utilizing patterned ipsc-derived cortical neurons integrated with microelectrode arrays. Sci Rep. 2024 <\/p>\n\n\n\n

Gallo LH, Akanda N, Autar K, Patel A, Cox I, Powell HA, Grillo M, Barakat N, Morgan D, Guo X, Hickman JJ. A functional aged human iPSC\u2010cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics. Alzheimer’s & Dementia. 2024.<\/p>\n\n\n\n

Rupar MJ, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman JJ. Modelling the innate immune system in microphysiological systems. Lab on a Chip. 2024.<\/p>\n\n\n\n

Caneus J, Autar K, Akanda N, Grillo M, Long C, Jackson M, Lindquist S, Guo X, Morgan D, Hickman JJ. Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays. 2024.<\/p>\n\n\n\n

Barakat N, Jangir H, Gallo L, Grillo M, Guo X, Hickman JJ. Inhibition of Metalloproteinases Extends Longevity and Function of In Vitro Human iPSC-Derived Skeletal Muscle. Biomedicines. 2024 Apr 12;12(4):856.<\/p>\n\n\n\n

2023<\/h2>\n\n\n\n

Guo X, Akanda N, Fiorino G, Nimbalkar S, Long CJ, Col\u00f3n A, Patel A, Tighe PJ, Hickman JJ. Human IPSC-Derived PreB\u00f6tC-Like Neurons and Development of an Opiate Overdose and Recovery Model. Adv Biol (Weinh). 2024 Aug;8(8):e2300276. doi: 10.1002\/adbi.202300276. Epub 2023 Sep 7. PubMed PMID: 37675827; PubMed Central PMCID: PMC10921423.<\/p>\n\n\n\n

Badu-Mensah A, Guo X, Mendez R, Parsaud H, Hickman JJ. The Effect of Skeletal Muscle-Specific Creatine Treatment on ALS NMJ Integrity and Function. Int J Mol Sci. 2023 Aug 31;24(17). doi: 10.3390\/ijms241713519. PubMed PMID: 37686322; PubMed Central PMCID: PMC10487911.<\/p>\n\n\n\n

Jangir H, Hickman JJ. Mimicking the Tendon Microenvironment to Enhance Skeletal Muscle Adhesion and Longevity in a Functional Microcantilever Platform. ACS Biomater Sci Eng. 2023 Aug 14;9(8):4698-4708. doi: 10.1021\/acsbiomaterials.3c00235. Epub 2023 Jul 18. PubMed PMID: 37462389; PubMed Central PMCID: PMC10430766.<\/p>\n\n\n\n

Rupar MJ, Sasserath T, Smith E, Comiter B, Sriram N, Long CJ, McAleer CW, Hickman JJ. Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation. Sci Rep. 2023 Jun 28;13(1):10509. doi: 10.1038\/s41598-023-35694-4. PubMed PMID: 37380653; PubMed Central PMCID: PMC10307889.<\/p>\n\n\n\n

Guo X, Akanda N, Fiorino G, Nimbalkar S, Long CJ, Col\u00f3n A, Patel A, Tighe PJ, Hickman JJ<\/strong>. Human IPSC\u2010Derived PreB\u00f6tC\u2010Like Neurons and Development of an Opiate Overdose and Recovery Model. Advanced Biology. 2023 Sep 7:2300276.<\/p>\n\n\n\n

Badu-Mensah A, Guo X, Mendez R, Parsaud H, Hickman JJ<\/strong>. The Effect of Skeletal Muscle-Specific Creatine Treatment on ALS NMJ Integrity and Function. Int J Mol Sci. 2023 Aug 31;24(17):13519.<\/p>\n\n\n\n

Jangir H, Hickman JJ<\/strong>. Mimicking the Tendon Microenvironment to Enhance Skeletal Muscle Adhesion and Longevity in a Functional Microcantilever Platform. ACS Biomater Sci Eng. 2023 Aug 14;9(8):4698-4708.<\/p>\n\n\n\n

M.J. Rupar, T. Sasserath, E. Smith, B. Comiter, N. Sriram, C.J. Long, C.W. McAleer, J.J. Hickman<\/strong>, \u201cDevelopment of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation,\u201d (accepted to Scientific Reports<\/em>, 2023).<\/p>\n\n\n\n

S. Nimbalkar, X. Guo, A. Col\u00f3n, M. Jackson, N. Akanda, A. Patel, M. Grillo and J.J. Hickman<\/strong>, \u201cDevelopment of a functional human induced pluripotent stem cell-derived nociceptor MEA system as a pain model for analgesic drug testing\u201d, Frontiers in Cell and Developmental Biology-Stem Cell Research<\/em>, 11:1011145 (2023). doi: 10.3389\/fcell.2023.1011145<\/p>\n\n\n\n

2022<\/h2>\n\n\n\n

J.W. Rumsey, C. Lorance, M. Jackson, T. Sasserath, C.W. McAleer, C.J. Long, A. Goswami, M.A. Russo, S.M. Raja, K.L. Gable, D. Emmett, L.D. Hobson-Webb, M. Chopra, J.F. Howard, Jr., J.T. Guptill, M.J. Storek, M. Alonso-Alonso, N. Atassi, S. Panicker, G. Parry, T. Hammond, J.J. Hickman<\/strong>, \u201cClassical complement pathway inhibition in a \u2018human-on-a-chip\u2019 model of autoimmune demyelinating neuropathies,\u201d Advanced Therapeutics<\/em> 2022:2200030 (2022). DOI: 10.1002\/adtp.202200030<\/p>\n\n\n\n

T. Sasserath, A.L. Robertson, R. Mendez, T.T. Hays, E. Smith, H. Cooper, N. Akanda, J.W. Rumsey, X. Guo, M. Might, S. Rodems, K. Baumgaertel, M. Pradhan, W. Zheng, A. Farkhondeh and J.J. Hickman<\/strong>, \u201cAn induced pluripotent stem cell-derived NMJ platform for study of the NGLY1-congenital disorder of deglycosylation,\u201d Advanced Therapeutics<\/em>, 2022: 2200009 (1-17) (2022). DOI: 10.1002\/adtp.202200009<\/p>\n\n\n\n

A. Badu-Mensah, X. Guo, S. Nimbalkar, Y. Cai, J.J. Hickman<\/strong>. \u201cALS mutations in both human skeletal muscle and motoneurons differentially affects neuromuscular junction integrity and function,\u201d Biomaterials<\/em>, 289:121752 (2022). DOI: doi.org\/10.1016\/j.biomaterials.2022.121752<\/p>\n\n\n\n

A. Badu-Mensah P. Valinski, H. Parsaud, J.J. Hickman, X. Guo. \u201cHyperglycemia negatively affects IPSC-derived myoblast proliferation and skeletal muscle regeneration and function,\u201d Cells<\/em>, 11:3674 (2022). DOI: 10.3390\/cells11223674<\/p>\n\n\n\n

Autar K, Guo X, Rumsey JW, Long CJ, Akanda N, Jackson M, Narasimhan NS, Caneus J, Morgan D, Hickman JJ.<\/strong> A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders. Stem Cell Reports. 2022 Jan 11;17(1):96-109. doi: 10.1016\/j.stemcr.2021.11.009.<\/p>\n\n\n\n

2021<\/h2>\n\n\n\n

Oleaga C, Bridges LR, Persaud K, McAleer CW, Long CJ, Hickman JJ.<\/strong> A functional long-term 2D serum-free human hepatic in vitro system for drug evaluation. Biotechnol Prog. 2021 Jan;37(1):e3069. doi: 10.1002\/btpr.3069.<\/p>\n\n\n\n

Slaughter VL, Rumsey JW, Boone R, Malik D, Cai Y, Sriram NN, Long CJ, McAleer CW, Lambert S, Shuler ML, Hickman JJ.<\/strong> Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation. Sci Rep. 2021 Jun 23;11(1):13159. doi: 10.1038\/s41598-021-92264-2.<\/p>\n\n\n\n

Badu-Mensah A, Guo X, Hickman JJ.<\/strong> ALS Skeletal Muscle: Victim or Culprit. Neurosci Chron. 2021;2(2):31-33. doi: 10.46439\/neuroscience.2.012.<\/p>\n\n\n\n

Smith VM, Nguyen H, Rumsey JW, Long CJ, Shuler ML, Hickman JJ.<\/strong> A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics. Front Cell Dev Biol. 2021 Nov 22;9:745897. doi: 10.3389\/fcell.2021.745897.<\/p>\n\n\n\n

2020<\/h2>\n\n\n\n

A. Patel, J.W. Rumsey, C. Lorance, C.J. Long, B. Lee, L. Tetard, S. Lambert and J.J. Hickman<\/strong>, \u201cMyelination and node of Ranvier formation in a human motoneuron – schwann cell serum-free co-culture,\u201d ACS Chem Neurosci In Press, Online First doi=10.1021\/acschemneuro.0c00287, 2020).<\/p>\n\n\n\n

C. Oleaga, V. Platt, L.R. Bridges, K. Persaud, C. McAleer, C. Long and J.J. Hickman<\/strong>, \u201cA functional long-term serum-free human hepatic in vitro system for drug evaluation,\u201d (Submitted to Biotechnol Prog, Accepted 2020.<\/p>\n\n\n\n

Najjar SA, Smith AST, Long CJ, McAleer CW, Cai Y, Srinivasan B, Martin C, Vandenburgh HH, Hickman JJ. A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment. Biotechnol Bioeng. 2020 Mar;117(3):736-747. doi: 10.1002\/bit.27231.<\/p>\n\n\n\n

Col\u00f3n A, Badu-Mensah A, Guo X, Goswami A, Hickman JJ. Differentiation of Intrafusal Fibers from Human Induced Pluripotent Stem Cells. ACS Chem Neurosci. 2020 Apr 1;11(7):1085-1092. doi: 10.1021\/acschemneuro.0c00055.<\/p>\n\n\n\n

Pires de Mello CP, Carmona-Moran C, McAleer CW, Perez J, Coln EA, Long CJ, Oleaga C, Riu A, Note R, Teissier S, Langer J, Hickman JJ. Microphysiological heart-liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery. Lab Chip. 2020 Feb 21;20(4):749-759. doi: 10.1039\/c9lc00861f. Epub 2020 Jan 23.<\/p>\n\n\n\n

T. Sasserath, J. W. Rumsey, C. W. McAleer, L. R. Bridges, C. J. Long, D. Elbrecht, F. Schuler, A. Roth, C. Bertinetti-LaPatki, M. L. Shuler, J. J. Hickman, \u201cDifferential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip,\u201d Adv. Sci. 7:2000323 (2020). https:\/\/doi.org\/10.1002\/advs.202000323<\/p>\n\n\n\n

Caneus J, Akanda N, Rumsey JW, Guo X, Jackson M, Long CJ, Sommerhage F, Georgieva S, Kanaan NM, Morgan D, Hickman JJ. A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study A\u03b242 and tau-induced pathophysiological effects on long-term potentiation. Alzheimers Dement (N Y). 2020 May 27;6(1):e12029. doi: 10.1002\/trc2.12029.<\/p>\n\n\n\n

M.T. Schnepper, J. Roles and J.J. Hickman<\/strong>, \u201cCharacterization of drug-polymer adsorption isotherms in body-on-a-chip systems by inverse liquid-solid chromatography,\u201d ACS Biomaterials Sci Eng, In Press, Online First doi=10.1021\/acsbiomaterials.0c00350, 2020).<\/p>\n\n\n\n

Guo X, Smith V, Jackson M, Tran M, Thomas M, Patel A, Lorusso E, Nimbalkar S, Cai Y, McAleer CW, Wang Y, Long CJ, Hickman JJ. A Human-Based Functional NMJ System for Personalized ALS Modeling and Drug Testing. Adv Ther (Weinh). 2020 Nov;3(11):2000133. doi: 10.1002\/adtp.202000133.<\/p>\n\n\n\n

Schnepper M, Roles J, Hickman JJ.<\/strong> Inverse liquid-solid chromatography to evaluate drug interactions with organosilane-modified polydimethylsiloxane for use in body-on-a-chip systems. Biotechnol Prog. 2020 Nov;36(6):e3048. doi: 10.1002\/btpr.3048.<\/p>\n\n\n\n

M.T. Schnepper, J. Roles and J.J. Hickman<\/strong>, \u201cInverse liquid solid chromatography to evaluate drug interactions with organosilane modified polydimethylsiloxane for use in body-on-a-chip systems,\u201d Biotechnol Prog, In Press, 2020).<\/p>\n\n\n\n

Badu-Mensah A, Guo X, McAleer CW, Rumsey JW, Hickman JJ.<\/strong> Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression.
Sci Rep. 2020 Aug 31;10(1):14302. doi: 10.1038\/s41598-020-70510-3.<\/p>\n\n\n\n

K. Autar, X. Guo, J.W. Rumsey, C. Long, N. Akanda, M. Jackson, N.S. Narasimhan, J. Caneus, D. Morgan, J.J. Hickman<\/strong>, \u201cA functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders,\u201d (Submitted to Cell Stem Cell 2020).<\/p>\n\n\n\n

Guo X, Badu-Mensah A, Thomas MC, McAleer CW, Hickman JJ.<\/strong> Characterization of Functional Human Skeletal Myotubes and Neuromuscular Junction Derived-From the Same Induced Pluripotent Stem Cell Source. Bioengineering (Basel). 2020 Oct 22;7(4):133. doi: 10.3390\/bioengineering7040133.<\/p>\n\n\n\n

Patel A, Rumsey JW, Lorance C, Long CJ, Lee B, Tetard L, Lambert S, Hickman JJ. Myelination and Node of Ranvier Formation in a Human Motoneuron-Schwann Cell Serum-Free Coculture. ACS Chem Neurosci. 2020 Sep 2;11(17):2615-2623. doi: 10.1021\/acschemneuro.0c00287.<\/p>\n\n\n\n

Characterization of Drug-Polymer Adsorption Isotherms in Body-on-a-Chip Systems by Inverse Liquid-Solid Chromatography. ACS Biomater Sci Eng. 2020 Aug 10;6(8):4462-4475. doi: 10.1021\/acsbiomaterials.0c00350.<\/p>\n\n\n\n

Bridges LR, Long CJ, Elbrecht D, Schuler F, Roth A, Bertinetti-LaPatki C, Shuler ML, Hickman JJ. Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip. Adv Sci (Weinh). 2020 Jun 2;7(13):2000323. doi: 10.1002\/advs.202000323.<\/p>\n\n\n\n

2019<\/h2>\n\n\n\n

C. Oleaga, A. Lavado, A. Riu, S. Rothemund, C.A. Carmona-Moran, K. Persaud, A. Yurko, J. Lear, N.S. Narasimhan, C.J. Long, F. Sommerhage, L.R. Bridges, Y. Cai, C. Martin, M.T. Schnepper, A. Goswami, R. Note, J. Langer, S. Teissier, J. Cotovio and J.J. Hickman<\/strong>, \u201cLong-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System,\u201d Adv. Funct. Mater. 2018:1805792 (2019) DOI: 10.1002\/adfm.201805792.<\/p>\n\n\n\n

J.H. Sung, Y. Wang, N.S. Narasimhan, M. Jackson, C. Long, J.J. Hickman<\/strong>, M.L. Shuler, \u201cRecent Advances in Body-on-a-Chip Systems,\u201d Anal. Chem. 91:330-351 (2019) DOI:10.1021\/acs.analchem.8b05293.<\/p>\n\n\n\n

N. Azim, C. Hart, F. Sommerhage, M. Aubin, A. Nguyen, J. Hickman and S. Rajaraman, \u201cPrecision Plating of Human Electrogenic Cells on Microelectrodes Enhanced with Precision Electrodeposited Nano-Porous Platinum for Cell-based Biosensing Applications,\u201d IEEE J. Microelectromech. Syst. 28(1):50-62 (2019) DOI: 10.1109\/JMEMS.2018.2879577<\/p>\n\n\n\n

C.W. McAleer, C.J. Long, D. Elbrecht, T. Sasserath, L.R. Bridges, J.W. Rumsey, C. Martin, M. Schnepper, Y. Wang, F. Schuler, A.B. Roth, C. Funk, M.L. Shuler, J.J. Hickman<\/strong>, \u201cMulti-Organ System for the Evaluation of efficacy and off-target toxicity of Anti-Cancer Therapeutics,\u201d Sci. Trans. Med. 11:eaav1386 (2019).<\/p>\n\n\n\n

C.W. McAleer, A. Pointon, C.J. Long, R. Brighton, B. Wilkin, L.R. Bridges, K. Fabre, R. McDougall, V.P. Muse, J.T. Mettetal, A. Srivastava, D.P. Williams, M. Schnepper, J. Roles, M.L. Shuler, J.J. Hickman<\/strong>, L. Ewart, \u201cOn the Potential of In Vitro Organ-Chip Models to Define Temporal Pharmacokinetic-Pharmacodynamic Relationships,\u201d Sci. Rep. 9:9619 (2019) https:\/\/doi.org\/10.1038\/s41598-019-45656-4.<\/p>\n\n\n\n

M. Gonzalez, X. Guo, M. Lin, M. Stancescu, P. Molnar, S. Spradling and J.J. Hickman<\/strong>, \u201cPolarity Induced in Human Stem Cell Derived Motoneurons on Patterned Self-Assembled Monolayers,\u201d ACS Chem. Neurosci. 10:2756-2764 (2019).<\/p>\n\n\n\n

C.P. Pires de Mello, J. Rumsey, V. Slaughter and J.J. Hickman<\/strong>, \u201cA Human-on-a-Chip Approach to Tackling Rare Diseases,\u201d DRUDIS 24:2139-2151 (2019). https:\/\/doi.org\/10.1016\/j.drudis.2019.08.001<\/p>\n\n\n\n

C. Oleaga, G. Jalilvand, G. Legters, C. Martin, G. Eckman, C.J. Long, J.J. Hickman<\/strong>, \u201cA Human In Vitro Platform for the Study of Pharmacology Strategies in Cardiac Ischemia,\u201d APL Bioeng. 3, 036103 (2019); doi: 10.1063\/1.5089237).<\/p>\n\n\n\n

E. LoRusso, J.J. Hickman<\/strong>, X. Guo, \u201cIon channel dysfunction and altered motoneuron excitability in ALS,\u201d Neurological Disorder and Epilepsy Journal 2(2):124 (2019).<\/p>\n\n\n\n

E.A. Coln, A. Colon, C.J. Long, N. Narasimhan Sriram, M. Esch, J.-M. Prot, D.H. Elbrecht, Y. Wang, M. Jackson, M.L. Shuler, J.J. Hickman<\/strong>, \u201cPiezoelectric BioMEMS Cantilever for Measurement of Muscle Contraction and for Actuation of Mechanosensitive Cells,\u201d MRS Commun. 9(4):1186-1192 (2019). DOI:https:\/\/doi.org\/10.1557\/mrc.2019.129<\/p>\n\n\n\n

J.J. Hickman<\/strong>, D. Huh, and R.D. Kamm, \u201cGuest Editorial: Microphysiological Systems,\u201d APL Bioengineering 3: 040401 (2019). DOI: 10.1063\/1.5130170.<\/p>\n\n\n\n

2018<\/h2>\n\n\n\n

Carlota Oleaga, Andrea Lavado, Anne Riu, Sandra Rothemund, Carlos A. Carmona-Moran, Keisha Persaud, Andrew Yurko, Jennifer Lear, Narasimhan Sriram Narasimhan, Christopher J. Long, Frank Sommerhage, Lee Richard Bridges, Yunqing Cai, Candace Martin, Mark T. Schnepper, Arindom Goswami, Reine Note, Jessica Langer, Silvia Teissier, Jos\u00e9 Cotovio, and James J. Hickman* Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. Advanced Functional Materials<\/p>\n\n\n\n

L. Ewart, E.-M. Dehne, K. Fabre, Susan Gibbs, J. Hickman, E. Hornberg, M. Ingelman-Sundberg, K.-J. Jang, D.R. Jones, V.M. Lauschke, U. Marx, Jerome T. Mettetal, A. Pointon, D. Williams, W.-H. Zimmermann, and P. Newham, \u201cApplication of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery,\u201d Annual Review of Pharmacology and Toxicology<\/em> 58:65-82 (2018).<\/p>\n\n\n\n

J. van der Valk, K. Bieback, C. Buta, B. Cochrane, W.G. Dirks, J. Fu, J.J. Hickman<\/strong>, C. Hohensee, R. Kolar, M. Liebsch, F. Pistollato, M. Schulz, D. Thieme, T. Weber, J. Wiest, S. Winkler and G. Gstraunthaler, \u201cFetal Bovine Serum (FBS) Past \u2013 Present \u2013 Future,\u201d ALTEX<\/em> 35:99-118 (2018)<\/p>\n\n\n\n

N. Santhanam, L. Kumanchik, X. Guo, F. Sommerhage, Y. Cai, M. Jackson, C. Martin, G. Saad, C.W. McAleer, Y. Wang, A. Lavado, C.J. Long, J.J. Hickman<\/strong>, \u201cStem Cell Derived Phenotypic Human Neuromuscular Junction Model for Dose Response Evaluation of Therapeutics,\u201d Biomaterials <\/em>166:64-78, 2018.<\/p>\n\n\n\n

B. Berry, A.S.T. Smith, C. J. Long, C. Martin and J.J. Hickman<\/strong>, \u201cPhysiological A\u03b2 Concentrations Produce a More Biomimetic Representation of the Alzheimer\u2019s Disease Phenotype in iPSC Derived Human Neurons,\u201d ACS Chem Neurosci<\/em> in press, 2018.<\/p>\n\n\n\n

2017<\/h2>\n\n\n\n

X. Guo, A. Colon, N. Akanda, S. Spradling, M. Stancescu, C. Martin, J.J. Hickman<\/strong>, \u201cTissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc with Human Stem Cells: Sensory Neuron Innervation of Intrafusal Muscle Fibers,\u201d Biomaterials<\/em> 122:179-187 (2017).<\/p>\n\n\n\n

Y. Wang, C. Oleaga, C. Long, M.B. Esch, C. McAleer, P.G. Miller; J.J. Hickman<\/strong> and M.L. Shuler, \u201cSelf-contained, Low-cost Body-on-a-Chip Systems for Drug Development,” Experimental Biology and Medicine Online<\/em> 0:1-13 DOI:10.1177\/1535370217694101 (2017).<\/p>\n\n\n\n

J. van der Valk, K. Bieback, C. Buta, B. Cochrane, W.G. Dirks, J. Fu, J.J. Hickman<\/strong>, C. Hohensee, R. Kolar, M. Liebsch, F. Pistollato, M. Schulz, D. Thieme, T. Weber, J. Wiest, S. Winkler and G. Gstraunthaler, \u201cFetal Bovine Serum (FBS): Past \u2013 Present \u2013 Future,\u201d ALTEX: Alternatives to Animal Experimentation Online<\/em> August 9, 2017; doi:10.14573\/ altex.1705101 (2017).<\/p>\n\n\n\n

Y.I. Wang, C. Carmona, J.J. Hickman<\/strong> and M.L. Shuler, \u201cMulti-Organ Microphysiological Systems for Drug Development: Strategies, Advances and Challenges,\u201d Advanced Healthcare Materials<\/em> 242: 1701\u20131713; doi.org\/10.1002\/adhm.201701000 (2017).<\/p>\n\n\n\n

A. Colon, X. Guo, N. Akanda, Y. Cai and J.J. Hickman<\/strong>, \u201cFunctional Analysis of Human Intrafusal Fiber Innervation by Human \u03b3-Motoneurons,\u201d Nature Scientific Reports<\/em> 7:17202; doi:10.1038\/s41598-017-17382-2 (2017).<\/p>\n\n\n\n

D. Edwards, F. Sommerhage, B. Berry, H. Nummer, B. Clymer, M. Stancescu, J.J. Hickman<\/strong>, \u201cComparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems,\u201d ACS Biomaterials Science & Engineering<\/em> 3:3525-3533 (2017).<\/p>\n\n\n\n

A. Lavado, X. Guo, N. Akanda, C. Martin, Y. Cai, D. Elbrecht, M. Tran, J.-P. Bryant, A. Colon, C.J. Long, S. Lambert, D. Morgan and J.J Hickman, \u201cEvaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential,\u201d International Journal of Pharmacy and Pharmaceuticals<\/em> 11:348-374 (2017).<\/p>\n\n\n\n

2016<\/h2>\n\n\n\n

Mahler G.J., Esch M.B., Stokol T., J.J. Hickman<\/strong>, M.L. Shuler. 2016. Body-on-a-chip systems for animal-free toxicity testing. Altern Lab Anim.<\/em><\/p>\n\n\n\n

Sakolish, C.M., M.B. Esch, J.J. Hickman<\/strong>, M.L. Shuler, and G.J. Mahler. 2016. Modeling barrier tissues in vitro: methods, achievements, and challenges. E Bio Medicine. [link<\/a>]<\/p>\n\n\n\n

Sakolish, C.M., M.B. Esch, J.J. Hickman<\/strong>, M.L. Shuler, and G.J. Mahler. 2016. Modeling barrier tissues in vitro: methods, achievements, and challenges. E Bio Medicine<\/em>. http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4816829\/<\/p>\n\n\n\n

C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M.B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M.L. Shuler and J.J. Hickman<\/strong> \u201cMulti-Organ toxicity demonstration in a functional human in vitro system composed of four organs\u201d Scientific Reports<\/em> (6):20030 (2016)<\/p>\n\n\n\n

2015<\/h2>\n\n\n\n

Srinivasan, B., Kolli, A.R., Esch, M.B., Abaci, H.E., Shuler, M.L., and J.J. Hickman<\/strong>. 2015. TEER measurement techniques for in vitro barrier model systems. J Lab Automation<\/em>. 20:107-126<\/p>\n\n\n\n

C.W. McAleer, A.S.T. Smith, S. Najjar, K. Pirozzi, C.J. Long and J.J. Hickman<\/strong>, \u201cMechanistic Investigation of Adult Myotube Response to Exercise and Drug Treatment in Vitro Using a Multiplexed Functional Assay System,\u201d J Appl Physiol<\/em> 117(11):1398-1405 (2015).<\/p>\n\n\n\n

B. Srinivasan, A.R. Kolli, M.B. Esch, H.E. Abaci, M.L. Shuler and J.J. Hickman<\/strong>, \u201cTEER Measurement Techniques for Organs-On-Chips Systems,\u201d JALA <\/em>20(2):107-126 (2015).<\/p>\n\n\n\n

C. McAleer, J.W. Rumsey, M. Stancescu and J.J. Hickman<\/strong>, \u201cFunctional Myotube Formation from Adult Rat Satellite Cells in a Defined Serum-Free System,\u201d Biotechnology Progress<\/em> 31(4):997-1003 (2015).<\/p>\n\n\n\n

M. Stancescu, P. Molnar, C. McAleer, W. McLamb, C. Long, C. Oleaga, J.-M. Prot and J.J. Hickman<\/strong>, \u201cIn Vitro Model of Whole Heart Function,\u201d Biomaterials<\/em> 60:20-30 (2015).<\/p>\n\n\n\n

B.J. Berry, N. Akanda, A.S.T. Smith, C.J. Long, M.T. Schnepper, X. Guo and J.J. Hickman<\/strong>, \u201cFunctional Characterization of Human Induced Pluripotent Stem Cell Neurons in Different Defined Culture Systems,\u201d Biotechnology Progress<\/em> in press (2015).<\/p>\n\n\n\n

2014<\/h2>\n\n\n\n

C.W. McAleer, A.S.T. Smith, S. Najjar, K. Pirozzi, C.J. Long and J.J. Hickman<\/strong>, \u201cMechanistic Investigation of Adult Myotube Response to Exercise and Drug Treatment in Vitro Using a Multiplexed Functional Assay System,\u201d J Appl Physiol<\/em> 117(11):1398-1405 (2014).<\/p>\n\n\n\n

Esch, M.B., Smith, A., Prot, J.M., Oleaga, C., Hickman, J., and Shuler, M.L. 2014. How Multi-Organ Microdevices Can Help Foster Drug Development. Advanced Drug Delivery Reviews<\/em>, 69-70 (2014) 158-169.<\/p>\n\n\n\n

Shuler, M.L. and J.J. Hickman<\/strong>. 2014. Toward in virtro models of brain structure and function. PNAS<\/em>. 111(38): 13682-13683.<\/p>\n\n\n\n

Sung, J.H., Srinivasan, B., Esch, M.B., McLamb, W.T., Bernabini, C., Shuler, M.L., and J.J. Hickman<\/strong>. 2014. Using physiologically-based pharmacokinetic-guided \u201cbody-on-a-chip\u201d systems to predict mammalian response to drug and chemical exposure. Experimental Biology and Medicine<\/em>. 239:1225-1239.<\/p>\n\n\n\n

X. Guo, K. Greene, N. Akanda, A.S.T. Smith, M. Stancescu, S. Lambert, H. Vandenburgh, and J.J. Hickman<\/strong>, \u201cIn vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System,\u201d Biomaterials Science <\/em>2:131-138 (2014).<\/p>\n\n\n\n

A.S.T. Smith, C.J. Long, B.J. Berry, C. McAleer, M. Stancescu, P. Molnar, P.G. Miller, M.B. Esch, J.-M. Prot, J.J. Hickman<\/strong> and M.L. Shuler, \u201cMicrophysiological systems and low cost microfluidic platform with analytics,\u201d Stem Cell Research and Therapy<\/em> in press (2014).<\/p>\n\n\n\n

M. B. Esch, A.S.T. Smith,J.-M. Prot, C. Oleaga, J.J. Hickman<\/strong> and M.L. Shuler \u201cHow Multi-Organ Microdevices Can Help Foster Drug Development\u201d ADDR<\/em> in press (2014).<\/p>\n\n\n\n

J.H. Sung, M.B. Esch, W.T. McLamb, C. Bernabini, B. Srinivasan, M.L. Shuler and J.J. Hickman<\/strong>, \u201cUsing PBPK guided \u201cBody-on-a-Chip\u201d Systems to Predict Mammalian Response to Drug and Chemical Exposure,\u201d accepted to Experimental Biology and Medicine<\/em> (2014).<\/p>\n\n\n\n

A.S.T. Smith, C.J. Long, C. McAleer, N. Bobbitt, B. Srinivasan and J.J. Hickman<\/strong>, \u201cUtilization of microscale silicon cantilevers to assess cellular contractile function in vitro,\u201d accepted to JoVE<\/em> (2014).<\/p>\n\n\n\n

M. Ramalingam, P, Molnar and J.J. Hickman<\/strong>, \u201cSurface Patterning of Biomaterials to Control Cell Behavior,\u201d Encyclopedia of Nanoscience and Nanotechnology(ENN)<\/em> American Scientific Publishers, Valencia, California, in press.<\/p>\n\n\n\n

2013<\/h2>\n\n\n\n

Smith, A.S., Long, C.J., Berry, B.J., Mcaleer, C., Molnar, P., Miller, P.G., Esch, M.B., Prot, J.M., Hickman, J.J. and Shuler, M.L. 2013. Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Res Ther. <\/em>DOI: 10.1186\/scrt370. PMID: 24565109. Epub 2013 Dec 20<\/p>\n\n\n\n

Angus, et al. 2013. A physical sciences network characterization of non-tumorigenic and metastatic cells, Sci. Rep. 3:14493 DOI:10.1038\/srep01449<\/p>\n\n\n\n

S.A. Khan, V. Thakore, A. Behal, L. B\u00f6l\u00f6ni and J.J. Hickman<\/strong>, \u201cComparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction,\u201d Journal of Computational and Theoretical Nanoscience<\/em>, 10(3):573-580 (2013).<\/p>\n\n\n\n

A. Natarajan, T. DeMarse, P. Molnar, J.J. Hickman<\/strong>, \u201cEngineered In Vitro Feed-Forward Networks,\u201d Journal of Biotechnology and Biomaterials <\/em>3(1):153 (2013).<\/p>\n\n\n\n

X. Guo, S. Spradling, M. Stancescu, S. Lambert, J.J. Hickman<\/strong>, \u201cDerivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1,\u201d Biomaterials<\/em> 34:4418-4427 (2013).<\/p>\n\n\n\n

J.H. Sung, M.B. Esch, J.-M. Prot, C.J. Long, A. Smith, J.J. Hickman<\/strong> and M.L. Shuler, \u201cMicrofabricated mammalian organ systems and their integration into models of whole animals and humans,\u201d Lab on a Chip <\/em>13:1201-1212 (2013).<\/p>\n\n\n\n

C. Finch, T. Clarke, and J.J. Hickman<\/strong>, \u201cA Continuum Hard-Sphere Model of Protein Adsorption,\u201d Journal of Computational Physics<\/em>, 244:212-222 (2013).<\/p>\n\n\n\n

J.W. Rumsey, C. McAleer, M. Das, A. Bhalkikar, K. Wilson, M. Stancescu, S. Lambert, J.J. Hickman<\/strong>, \u201cMyelination and node of Ranvier formation on sensory neurons in a defined in vitro system,\u201d In Vitro Cell Dev Biol Anim<\/em>, 49:608-618 (2013).<\/p>\n\n\n\n

K.L. Pirozzi C.J. Long, C.W. McAleer, A.S.T. Smith and J.J. Hickman<\/strong>, \u201cCorrelation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an Atomic Force Microscopy-based bio- Microelectromechanical systems device,\u201d Applied Physics Letters<\/em>, 103:083108 (2013).<\/p>\n\n\n\n

D. Edwards, M. Stancescu, P. Molnar and J.J. Hickman<\/strong>, \u201cTwo cell networks of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system,\u201d ACS Chemical Neuroscience<\/em> 4:1174-1182 (2013) DOI: 10.1021\/cn300206k<\/p>\n\n\n\n

A.S.T. Smith, C.J. Long, Kristen Pirozzi and J.J. Hickman<\/strong>, \u201cDevelopment of a functional system for high-content screening of neuromuscular junctions,\u201d Technology<\/em>, 1(1):37-48 (2013).<\/p>\n\n\n\n

2012<\/h2>\n\n\n\n

K.A. Wilson, C. A. Finch, P. Anderson, F. Vollmer, and J.J. Hickman<\/strong>, \u201cWhispering Gallery Mode Biosensor Quantification of Fibronectin Adsorption Kinetics onto Alkylsilane Monolayers and Interpretation of Resultant Cellular Response\u201d Biomaterials<\/em> 33:225-236 (2012).<\/p>\n\n\n\n

H. Davis, X. Guo, S. Lambert, M. Stancescu and J.J. Hickman<\/strong>, \u201cSmall Molecule Induction of Human Umbilical Stem Cells into MBP-Positive Oligodendrocytes in a Defined Three-Dimensional Environment,\u201d ACS Chemical Neuroscience<\/em> 3:31-39 (2012).<\/p>\n\n\n\n

X. Guo, J.E. Ayala1, M. Gonzalez, M. Stancescu, S. Lambert, J.J. Hickman<\/strong>, \u201cTissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons,\u201d Biomaterials<\/em> 33(23):5723-5731 (2012).<\/p>\n\n\n\n

C. Long, C. Finch, M. Esch, W. Anderson, M. Shuler and J.J. Hickman<\/strong>, \u201cDesign Optimization of Liquid-Phase Flow Patterns for Microfabricated Lung On A Chip,\u201d Annals of Biomedical Engineering<\/em> 40(6):1255-1267 (2012).<\/p>\n\n\n\n

H. Davis, M. Gonzalez, N. Bhargava, M. Stancescu, J.J. Hickman<\/strong>, and S. Lambert, \u201cRat Cortical Oligodendrocyte\u2013Embryonic Motoneuron Co-culture: An in vitro Axon-Oligodendrocyte Interaction Model,\u201d Journal of Biomaterials & Tissue Engineering<\/em> 2(3):206-214 (2012).<\/p>\n\n\n\n

V. Thakore, P. Molnar and J.J. Hickman<\/strong>, \u201cAn Optimization Based Study of Equivalent Circuit Models for Representing Recordings at the Neuron-Electrode Interface,\u201d IEEE Transactions on Biomedical Engineering<\/em> 59(8):2338-2347 (2012).<\/p>\n\n\n\n

C. Wang, J. Reed, L. Ma, Y. Qiao, Y. Luo, S. Zou, J.J. Hickman<\/strong> and M. Su, \u201cBiomimic Light Trapping Silicon Nanowire Arrays for Laser Desorption\/Ionization of peptides,\u201d Journal of Physical Chemistry C<\/em> 116(29):15415-15420 (2012).<\/p>\n\n\n\n

C.N. Baker, D.G. Taylor, K. Osuala, A. Natarajan, P. Molnar, J.J. Hickman<\/strong>, S. Alam, B. Moscato, D. Weinshenker, and S.N. Ebert, \u201cAdrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heart,\u201d Biochemical and Biophysical Research Communications<\/em> 423(3):536-541 (2012).<\/p>\n\n\n\n

X. Guo, J.J. Hickman<\/strong>. \u201cTreatment of ALS utilizing a stem cell strategy\u201d in Motor Neuron Diseases: Causes, Classification and Treatments<\/em> Eds. B.J. Turner, J.B. Atkin, Nova Science Publishers, Hauppauge, New York. pp.115-136 (2012).<\/p>\n\n\n\n

2011<\/h2>\n\n\n\n

K. Wilson, M. Stancescu, M. Das, J.W. Rumsey and J.J. Hickman<\/strong>, \u201cDirect Patterning of Coplanar Peg Alkylsilane Monolayers by Deep \u2013Ultraviolet Photolithograpy as a General Method for Long-Term Cell Patterning and Culture,\u201d JVST B<\/em> 29(2):021020 (2011).<\/p>\n\n\n\n

A. Natarajan, M. Stancescu, V. Dhir, C. Armstrong, F. Sommerhage, J.J. Hickman<\/strong> and P. Molnar, \u201cPatterned Cardiomyocytes on Microelectrode Arrays as a Device for Studying Cardiac Electrophysiology and Drug Effects,\u201d Biomaterials<\/em> 32(18):4267-4274 (2011).<\/p>\n\n\n\n

X. Guo, M. Gonzalez, M. Stancescu, H. Vandenburgh, J.J. Hickman<\/strong>, \u201cNeuromuscular Junction Formation between Human Stem cell-derived Motoneurons and Human Skeletal Muscle in a Defined System,\u201d Biomaterials<\/em> 32:9602-9611 (2011).<\/p>\n\n\n\n

2010<\/h2>\n\n\n\n

M.S. Ravenscroft-Chang, J. Stohlman, P. Molnar, A. Natarajan, H.E. Canavan, M. Teliska, M. Stancescu, V. Krauthamer and J.J. Hickman<\/strong>, \u201cAltered Calcium Dynamics in Cardiac Cells Grown on Silane-Modified Surfaces,\u201d Biomaterials<\/em> 31:602-607 (2010).<\/p>\n\n\n\n

C.M. Smith, T.D. Roy, A. Bhalkikar, B. Li, J.J. Hickman<\/strong> and K.H. Church, \u201cEngineering a Titanium and Polycaprolactone Construct for a Biocompatible Interface Between the Body and Artificial Limb,\u201d Tissue Engineering Part A<\/em> 16(2):717-724 (2010). X.F. Guo, K. Johe, P. Molnar, H. Davis, J.J. Hickman<\/strong>, \u201cCharacterization of a Human Spinal Cord Stem Cell Line and Its Induction to Motoneurons,\u201d Tissue Engineering and Regenerative Medicine<\/em> 4:181-193 (2010).<\/p>\n\n\n\n

K. Varghese, P. Molnar, M. Das, N. Bhargava, S. Lambert, M.S. Kindy and J.J. Hickman<\/strong>, \u201cA New Target for Amyloid Beta Toxicity Validated by Standard and High-throughput Electrophysiology,\u201d PLoS One<\/em> 5(1): e8643. doi:10.1371\/journal.pone.0008643 (2010).<\/p>\n\n\n\n

M. Das, J.W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman<\/strong>, \u201cA Defined Long-Term In Vitro Tissue Engineered Model of Neuromuscular Junctions,\u201d Biomaterials<\/em> 31:4880-4888 (2010).<\/p>\n\n\n\n

K. Wilson, M. Das, K.J. Wahl, R.J. Colton and J.J. Hickman<\/strong>, \u201cMeasurement of Contractile Stress Generated by Cultured Muscle on Silicon Cantilevers,\u201d PLoS One<\/em> 5(6): e11042. doi: 10.1371\/journal.pone.0011042 (2010).<\/p>\n\n\n\n

D. Edwards, M. Das, P. Molnar and J.J. Hickman<\/strong>, \u201cAddition of Glutamate to Serum Free Culture Promotes Recovery of Electrical Activity in Adult Hippocampal Neurons In Vitro,\u201d J Neuroscience Methods<\/em> 190:155-163 (2010).<\/p>\n\n\n\n

L. Chi, J. Yu, H. Zhu, X. Li, S. Zhu, Z. Li, L.C. Pettigrew, D. Grass, J.J. Hickman<\/strong>, M.S. Kindy, \u201cDual Neuronal Response to Tumor Necrosis Factor-alpha Following Spinal Cord Injury,\u201d Neural Regeneration Research<\/em> 5(12):917-926 (2010).<\/p>\n\n\n\n

J.W. Rumsey, M. Das, A. Bhalkikar, M. Stancecsu and J.J. Hickman<\/strong>, \u201cTissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc: Sensory Neuron Innervation of Intrafusal Muscle Fibers,\u201d Biomaterials<\/em> 31:8218-8227 (2010).<\/p>\n\n\n\n

N. Bhargava, M. Das, D. Edwards, M. Stancescu, J.-F. Kang and J.J. Hickman<\/strong>, \u201cCoexpression of Glutamate Vesicular Transporter (VGLUT1) and Choline Acetyltransferase (ChAT) Proteins in Embryonic Rat Hippocampal Neurons in Culture,\u201d In Vitro Cell Dev Animal<\/em> 46:685-692 (2010).<\/p>\n\n\n\n

C. Wang, L. Ma, M. Hossain, H. Wang, S. Zou, J.J. Hickman<\/strong>, M. Su, \u201cDirect visualization of molecular scale chemical adsorptions on solids using plasmonic nanoparticle arrays,\u201d Sensors and Actuators, B:Chemical<\/em> 150(2):667-672 (2010).<\/p>\n\n\n\n

C. Wang, M. Hossain, L. Ma, Z. Ma, J.J. Hickman<\/strong>, M. Su, \u201cHighly Sensitive Thermal Detection of Thrombin Using Aptamer-Functionalized Phase Change Nanoparticles,\u201d Biosensors & Bioelectronics<\/em> 26(2):437-43 (2010).<\/p>\n\n\n\n

J.C. Henderson, M. Yacopucci, C.J. Chun, K. Lenghaus and J.J. Hickman<\/strong>, \u201cInvestigation of the Behavior of Serum Plasma in a Microfluidics System,\u201d JVST B<\/em> 28(5):1066-1069 (2010).<\/p>\n\n\n\n

X. Guo, M. Das, J. Rumsey, M. Gonzalez, M. Stancescu and J.J. Hickman<\/strong>, \u201cNeuromuscular Junction Formation between Human Stem Cell derived Motoneurons and Rat Skeletal Muscle in a Defined System,\u201d Tissue Engineering, Part C<\/em> 16(6):1347-1355 (2010).<\/p>\n\n\n\n

M. Ramalingam, S.S. Liao, S. Ramakrishna, P. Molnar, Z.M. Huang, M. Kotaki, K. Panduranga Rao and J.J. Hickman<\/strong>, \u201cSkeletal Regeneration Nanobiomaterials,\u201d in Biomaterials for Bone, Regenerative Medicine<\/em>, TTP Publishers, Swiss\/USA, (2010).<\/p>\n\n\n\n

2009<\/h2>\n\n\n\n

K. Varghese, M. Das, N. Bhargava, P. Molnar, M.S. Kind and J.J. Hickman<\/strong>, \u201cRegeneration and Characterization of Adult Mouse Hippocampal Neurons in a Defined In Vitro System,\u201d Journal of neuroscience methods<\/em> 177:51-59 (2009).<\/p>\n\n\n\n

M. Ramalingam, P. Molnar, K. P. Rao and J. J. Hickman, \u201cBiomaterial Surface Patterning Utilizing Self Assembled Monolayers to Control Neuronal Cell Behavior,\u201d Int. Journal of Biomedical Engineering and Technology, Review<\/em> 2(2):104-134 (2009).<\/p>\n\n\n\n

J.W. Rumsey, M. Das, M. Stancescu, M. Bott, C. Fernandez-Valle and J.J. Hickman<\/strong>, \u201cNode of Ranvier Formation on Motoneurons In Vitro,\u201d Biomaterials<\/em> 30:3567-3572 (2009).<\/p>\n\n\n\n

T. Xu, P, Molnar, C. Gregory, M. Das, T. Boland and J.J. Hickman<\/strong>, \u201cElectrophysiological Characterization of Embryonic Hippocampal Neurons Cultured in 3D Collagen Hydrogel,\u201d Biomaterials<\/em> 30:4377-4383 (2009).<\/p>\n\n\n\n

M. Das, J. W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman<\/strong>, \u201cSkeletal Muscle Tissue Engineering: An Improved Model Promoting Long Term Survival of Myotubes, Structural Development of E-C Coupling Apparatus and Neonatal Myosin Heavy Chain (MHC) Expression,\u201d Biomaterials<\/em> 30:5392-5402 (2009).<\/p>\n\n\n\n

M. Das, J.W. Rumsey, N. Bhargava, C. Gregory, L. Riedel, J.F. Kang, J.J. Hickman<\/strong>, \u201cDeveloping a Novel Serum-Free Cell Culture Model of Skeletal Muscle Differentiation by Systematically Studying the Role of Different Growth Factors in Myotube Formation,\u201d In Vitro Cell Dev Biol Animal<\/em> 45:378-387 (2009).<\/p>\n\n\n\n

N. Akanda, M. Stancescu, P. Molnar and J.J. Hickman<\/strong>, \u201cAnalysis of Toxin Induced Changes in Action Potential Shape for Drug Development,\u201d Journal of Biomolecular Screening<\/em> 14(10):1228-1235 (2009).<\/p>\n\n\n\n

N. Bhargava, M. Das, A. S. Karakoti, S. Patil, J.F. Kang, M. Stancescu, M. S. Kindy, S. Seal and J.J. Hickman<\/strong>, \u201cRegeneration of Adult Mice Motoneurons Utilizing a Defined System and Anti-oxidant Nanoparticles,\u201d Journal of Nanoneuroscience<\/em> 1(2):130-143 (2009).<\/p>\n\n\n\n

D.G. Taylor, A. Natarajan, B. Moscato, P. Molnar, J.J. Hickman<\/strong>, S.N. Ebert, \u201cAdrenergic Deficiency Leads to Slowed Ventricular Conduction and Increased Arrhythmias in Embryonic Mouse Hearts,\u201d Circulation<\/em> 120(18):S616 (2009).<\/p>\n\n\n\n

2008<\/h2>\n\n\n\n

M. Das, N. Bhargava, A. Bhalkikar, J. F. Kang and J. J. Hickman, \u201cTemporal Neurotransmitter Conditioning Restores the Functional Activity of Adult Spinal-Cord Neurons in Long-Term Culture,\u201d Experimental Neurology<\/em> 209:171-180 (2008).<\/p>\n\n\n\n

J.W. Rumsey, M. Das, J.F. Kang, R. Wagner, P. Molnar and J.J Hickman, \u201cTissue Engineering Intrafusal Fibers: Dose and Time Dependent Differentiation of Nuclear Bag Fibers in a Defined In Vitro System using Neuregulin 1-\u03b2-1,\u201d Biomaterials<\/em> 29:994-1104 (2008).<\/p>\n\n\n\n

J. Liu, J.W. Rumsey, P. Molnar, M. Das, C. Gregory, L. Riedel and J.J. Hickman<\/strong>, \u201cElectrophysiological and Immunocytochemical Characterization of DRG Neurons on an Organosilane Surface in Serum Free Medium,\u201d In Vitro Cellular & Developmental Biology<\/em> 44:162-168 (2008).<\/p>\n\n\n\n

A. Natarajan, C.J. Chun, J.J. Hickman<\/strong> and P. Molnar, “Growth and Electrophysiological Properties of Rat Embryonic Cardiomyocytes on Hydroxyl- and Carboxyl-Modified Surfaces,\u201d Journal of Biomaterials Science: Polymer Edition<\/em> 19(10):1319-1331 (2008).<\/p>\n\n\n\n

V. Thakore, A. Behal, P. Molnar, D.C. Leistritz, and J.J. Hickman<\/strong>, \u201cNanoscale Nonlinear Dynamic Characterization of the Neuron-Electrode Junction,\u201d J. Comput. Theor. Nanosci.<\/em> 5(11):2164-2169 (2008).<\/p>\n\n\n\n

J. Rolland, K-S. Lee, A. Mahmood, L. Fluck, J. Duarte, I. Kaya, A. Santhanam, P. Meemon, S. Murali, O. Ilegbusi, P. Kupelian, A.M. Kachurin, W.L. Warren, P. Molnar, J.J. Hickman<\/strong> and P.K. Kolattukudy, Eds J.D. Westwood, R.S. Haluck, H.M.Hoffman, G.T. Mogel, R. Phillips, R.A. Robb and K.G. Vosburgh, \u201cCollaborative Engineering: 3-D Optical Imaging and Gas Exchange Simulation of In-Vitro Alveolar Constructs,\u201d in Studies in Health Technolology Informatics<\/em> 132:426-432 (2008).<\/p>\n\n\n\n

Rolland, J. P., K. S. Lee, A. Mahmood, L. Fluck, J. Duarte, I. Kaya, A. Santhanam, P. Meemon, S. Murali, O. Ilegbusi, P. Kupelian, W. L. Warren, P. Molnar, J. J. Hickman and P. E. Kolattukudy. Collaborative Engineering: 3-D Optical Imaging and Gas Exchange Simulation of In-Vitro Alveolar Constructs. Medicine Meets Virtual Reality 16 – parallel, combinatorial, convergent: NextMed by Design<\/em>. J. D. Westwood, R. S. Haluck, H. M. Hoffmanet al. 132. (2008).<\/p>\n\n\n\n

M. Ramalingam, P, Molnar and J.J. Hickman<\/strong>, \u201cNano-Surface Patterning Techniques for Cell Studies,\u201d Encyclopedia of Nanoscience and Nanotechnology<\/em> (ENN) American Scientific Publishers, Valencia, California, (2008).<\/p>\n\n\n\n

M. Ramalingam, S. Ramakrishna and J.J. Hickman<\/strong>, \u201cCell Responsive Nano-fibrous Materials for Tissue Engineering,\u201d in Encyclopedia of Nanoscience and Nanotechnology<\/em>, American Scientific Publishers, Ed. Hari Singh Nalwa, Valencia, California, (2008).<\/p>\n\n\n\n

2007<\/h2>\n\n\n\n

M. Das, S. Patil, N. Bhargava, J.F. Kang, L. Riedel, S. Seal and J.J. Hickman<\/strong>, \u201cAuto-catalytic Ceria Nanoparticles Offer Neuroprotection to Adult Rat Spinal Cord Neurons,\u201d Biomaterials<\/em> 28:1918-1925 (2007).<\/p>\n\n\n\n

P. Molnar, W. Wang, A. Natarajan, J.W. Rumsey and J.J. Hickman<\/strong>, \u201cPhotolithographic Patterning of C2C12 Myotubes using Vitronectin as Growth Substrate in Serum-Free Medium,\u201d Biotechnology Progress<\/em> 23(1): 265-268 (2007).<\/p>\n\n\n\n

M. Das, J.W. Rumsey, C.A. Gregory, N. Bhargava, J.F. Kang, P. Molnar, L. Riedel, J.J. Hickman<\/strong>, \u201cEmbryonic Motor Neuron-Skeletal Muscle Co-culture in a Defined System,\u201d Neuroscience<\/em> 146:481-488 (2007).<\/p>\n\n\n\n

K. Wilson, P. Molnar and J.J. Hickman<\/strong>, \u201cIntegration of Functional Myotubes with a Bio-MEMS Device for Non-Invasive Interrogation,\u201d Lab-on-a-Chip<\/em> 7:920-922 (2007).<\/p>\n\n\n\n

M. Das, K. Wilson, P. Molnar and J.J. Hickman<\/strong>, \u201cDifferentiation of Skeletal Muscle and Integration of Myotubes with Silicon Microstructures using Serum-Free Medium and a Synthetic Silane Substrate,\u201d Nature Protocols<\/em> 2(7):1795-1801 (2007).<\/p>\n\n\n\n

P. Molnar, J.J. Hickman<\/strong>, \u201cModeling of action potential generation in NG108-15 cells,\u201d Methods Mol. Biol.<\/em> 403:175-84 (2007).<\/p>\n\n\n\n

P. Molnar P, JF. Kang, N. Bhargava, M. Das and J.J. Hickman<\/strong>, \u201cSynaptic connectivity in engineered neuronal networks.\u201d Methods Mol. Biol.<\/em> 403:165-73 (2007).<\/p>\n\n\n\n

P. Molnar, J.F. Kang, N. Bhargava, M. Das and J.J. Hickman<\/strong>, \u201cSynaptic Connectivity in Engineered Neuronal Networks,\u201d in Patch Clamp Methods and Protocols Humana Press Methods in Molecular Biology Series<\/em>, (July 2007).<\/p>\n\n\n\n

P. Molnar and J.J. Hickman<\/strong>, \u201cModeling of Action Potential Generation inNG108-15 Cells,\u201d in Patch Clamp Methods and Protocols Humana Press Methods in Molecular Biology Series<\/em>, (July 2007).<\/p>\n\n\n\n

2006<\/h2>\n\n\n\n

A. Natarajan, P. Molnar, K. Sieverdes, K. Jamshidi and J.J. Hickman<\/strong>, \u201cMultielectrode Recordings of Cardiac Action Potentials as a High Throughput Method to Evaluate Pesticide Toxicity,\u201d Toxicology In Vitro<\/em> 20(3):375-381 (2006).<\/p>\n\n\n\n

D. K Mohan, P. Molnar and J.J. Hickman<\/strong>. \u201cToxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells,\u201d Biosensors & Bioelectronics<\/em> 21:1804-1811 (2006).<\/p>\n\n\n\n

M. Das, C. Gregory, K. Wilson, P. Molnar, L. Riedel and J.J. Hickman<\/strong>, \u201cA Defined System to Allow Skeletal Muscle Differentiation and Subsequent Integration with Silicon Microstructures,\u201d Biomaterials<\/em> 27(24):4374-4380 (2006).<\/p>\n\n\n\n

S. Krishnamoorthy, J. Feng, A. Henry, L. Locascio, J.J. Hickman<\/strong> and S. Sundaram, \u201cSimulation and Experimental Characterization of Electroosmotic Flow in Surface Modified Channels,\u201d Microfluidics and Nanofluidics<\/em> 2:345-355 (2006).<\/p>\n\n\n\n

D. Henry, K. Lenghaus, K.A. Wilson, M. Hirsch-Kuchma, J. Jenkins, S. Sundaram and J.J. Hickman<\/strong>, \u201cSubmonolayer Measurements of Adsorbed Proteins In Microfluidic Channels,\u201d in Bionanotechnology: Proteins to Nanodevices<\/em> (V. Renugopalakrishnan, Randy V Lewis, Pawan K Dhar), Dordrecht, The Netherlands: Springer Press, (2006).<\/p>\n\n\n\n

2005<\/h2>\n\n\n\n

T. Xu, J. Jin, C. Gregory, J.J. Hickman<\/strong> and T. Boland, \u201cInkjet Printing of Viable Mammalian Cells,\u201d Biomaterials<\/em> 26(1):93-99 (2005).<\/p>\n\n\n\n

A. Behal, D.M. Dawson, P. Molnar and J.J. Hickman<\/strong>, \u201cThe stretch reflex arc: simulation, control and identification\u201d (http:\/\/pegasus.cc.ucf.edu\/~pmolnar\/bio-paper_journal2.pdf) (2005)<\/p>\n\n\n\n

M. Das, N. Bhargava, C. Gregory, L. Riedel, P. Molnar and J.J. Hickman<\/strong>, \u201cAdult Rat Spinal Cord Culture on an Organosilane Surface in a Novel Serum-Free Medium\u201d In Vitro Cell Dev Biol- Animal<\/em> 41:343-348 (2005).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, \u201cBuilding Minimalistic Hybrid Neuroelectric Devices,\u201d in Toward Replacement Parts for the Brain: Implantable Biomimetic Electronics as Neural Prosthetic<\/em> (T.W. Berger and D.L. Glanzman Eds.), 1st edition. Cambridge, MA: MIT Press (2005).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, P. Molnar, M. Hirsch-Kuchma, J.W. Rumsey, K. Wilson \u201cBiosurface Engineering, Cell Patterning,\u201d in Wiley Encyclopedia of Medical Devices and Instrumentation<\/em> (John G. Webster), 2nd edition. Hoboken, NJ: John Wiley & Sons, Inc. (2005)<\/p>\n\n\n\n

2004<\/h2>\n\n\n\n

T. Xu, S. Petridou, E. Lee, E. Roth, N. Vyavahare, J.J. Hickman<\/strong> and T. Boland, \u201cConstruction of High-Density Bacterial Colony Arrays and Patterns by the Ink-jet Method,\u201d Journal of Biotechnology & Bioengineering<\/em> 85:29 (2004).<\/p>\n\n\n\n

E. A. Roth, T. Xu, M. Das, C. Gregory, J.J. Hickman<\/strong> and T. Boland, \u201cInkjet Printing for High Throughput Cell Patterning,\u201d Biomaterials<\/em> 25(17): 3707-3715 (2004).<\/p>\n\n\n\n

J.K. Evju, P.B. Howell, L.E. Locascio, M.J. Tarlov and J.J. Hickman<\/strong>, \u201cAtmospheric Pressure Microplasmas for Modifying Sealed Microfluidic Devices,\u201d Applied Physics Letters<\/em> 84(10):1668-1670 (2004).<\/p>\n\n\n\n

B. Sweryda-Krawiec, H. Devaraj, G. Jacob, and J.J. Hickman<\/strong>, \u201cA New Interpretation of Serum Albumin Surface Passivation,\u201d Langmuir<\/em> 20(6):2054-2056 (2004).<\/p>\n\n\n\n

M. Das, P Molnar, C. Gregory, L. Riedel and J.J. Hickman<\/strong>, \u201cLong-term Culture Of Embyonic Rat Cardiomyocytes on an Organosilane Surface in a Serum Free Medium,\u201d Biomaterials<\/em> 25(25):5643-5647 (2004).<\/p>\n\n\n\n

F. Jin, J.J. Hickman<\/strong>, K. Lenghaus and R. Marcus, \u201cTotal Protein Determinations by Particle Beam\/Hollow Cathode Optical Emission Spectroscopy (PB\/HC-OES)System II: Improved Sensitivity Through Use of Silica Micro-particles as Carrier Agents for Enhanced Particle Transport,\u201d Journal of Analytical Atomic Spectrometry<\/em> 19(9):1199-1205 (2004).<\/p>\n\n\n\n

F. Jin, J.J. Hickman<\/strong>, K. Lenghaus, R. Marcus, \u201cTotal Protein Determinations by Particle Beam\/Hollow Cathode Optical Emission Spectroscopy (PB\/HC-OES) System III: Investigation of Carrier Salts for Enhanced Particle Transport,\u201d Anal Bioanal Chem.<\/em> 380 (2):204-211 (2004).<\/p>\n\n\n\n

J. Jenkins, B. Prabhakarpandian., K. Lenghaus, J.J. Hickman<\/strong>, S. Sundaram, \u201cFluidics Resolved Analysis of Protein Adsorption in a Biomicrofluidic System,\u201d Analytical Biochem<\/em> 331:207-215 (2004).<\/p>\n\n\n\n

Select Publications from pre-2004<\/h2>\n\n\n\n

K. Lenghaus, J. Dale, C. Henderson, D. Henry, E. Loghin and J.J. Hickman<\/strong>, \u201cEnzymes as Ultra-Sensitive Probes for Adsorption in Flow Systems,\u201d Langmuir<\/em> 19:5971 (2003).<\/p>\n\n\n\n

M.S. Ravenscroft, K.E. Bateman, K.M. Shaffer, H.M. Schessler, D.R. Jung, T.W. Schneider, C.B. Montgomery, T.L. Custer, A.E. Schaffner, Q.Y. Liu, Y.X. Li, J.L. Barker and J.J. Hickman<\/strong>, \u201cDevelopmental Neurobiology Implications from Fabrication and Analysis of Hippocampal Neuronal Networks on Patterned Silane-Modified Surfaces,\u201d J. Amer. Chem. Soc.<\/em> 120:12169 (1998).<\/p>\n\n\n\n

D.A. Stenger, J.J. Hickman<\/strong>, K.E. Bateman, M.S. Ravenscroft, W. Ma, J.J. Pancrazio, K.M. Shaffer, A.E. Schaffner, D.H. Cribbs and C.W. Cotman, \u201cMicrolithographic Definition of Axonal\/Dendritic Polarity in Cultured Hippocampal Neurons,\u201d J. Neuroscience Methods<\/em> 82:167 (1998).<\/p>\n\n\n\n

D.R. Jung, D.S. Cuttino, J.J. Pancrazio, P. Manos, T. Custer, R.S. Sathanoori, L.E. Aloi, M.G. Coulombe, M.A. Czarnaski, D.A. Borkholder, G.T. Kovacs, P. Bey, D.A. Stenger and J.J. Hickman<\/strong>, \u201cCell-Based Sensor Microelectrode Array Characterized by Imaging XPS, SEM, Impedance Spectroscopy, and Cellular Recordings,\u201d J. Vac. Sci. Tech. A<\/em> 16:1183 (1998).<\/p>\n\n\n\n

A.E. Schaffner, J.L. Barker, D.A. Stenger and J.J. Hickman<\/strong>, \u201cInvestigation of the Factors Necessary for Growth of Hippocampal Neurons in a Defined System,\u201d J. Neuroscience Methods<\/em> 62:111 (1995).<\/p>\n\n\n\n

D.A. Stenger and J.J. Hickman<\/strong>, \u201cLithographic Definition of Neuronal Microcircuits,\u201d in: Enabling Technologies for Cultured Neural Networks<\/em> (D.A. Stenger and T.M. McKenna, Eds.), 1st edition. San Diego: Academic Press, Inc. 77 (1994).<\/p>\n\n\n\n

J.J. Hickman<\/strong> and D.A. Stenger, \u201cInteractions of Cultured Neurons with Defined Surfaces,\u201d in: Enabling Technologies for Cultured Neural Networks<\/em> (D.A. Stenger and T.M. McKenna, Eds.), 1st edition. San Diego: Academic Press, Inc. 51 (1994).<\/p>\n\n\n\n

B.J. Spargo, M.A. Testoff, T.B. Nielsen, D.A. Stenger, J.J. Hickman<\/strong> and A.S. Rudolph, \u201cAdhesion, Spreading, and Differentiation of Endothelial Cells on Self-Assembled Amino- and Perfluoro-Alkylsilane Monolayers,\u201d Proc. Nat. Acad. Sci. USA<\/em> 91:11070 (1994).<\/p>\n\n\n\n

D.A. Stenger, C. Pike, J.J. Hickman<\/strong> and C.W. Cotman, \u201cSurface Determinants of Neuronal Survival and Growth on Self-Assembled Monolayers in Culture,” Brain Res.<\/em> 630:136 (1993).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, G.L. Bergeron, M.A. Czarnaski, and D.A. Kirkpatrick, \u201cSurface Chemistry of TaSi2-Si Eutectic Cold Cathodes and the Effect on Vacuum Field Emission,\u201d Appl. Phys. Lett.<\/em> 61:2518 (1992).<\/p>\n\n\n\n

D.A. Stenger, J.H. Georger, C.S. Dulcey, J.J. Hickman<\/strong>, A.S. Rudolph, T.B. Nielson, S. McCort, and J.M. Calvert, \u201cCoplanar Molecular Assemblies of Amino- and Perfluorinated Alkylsilanes: Characterization and Geometric Definition of Mammalian Cell Cultures,\u201d J. Am. Chem. Soc.<\/em> 114:8435 (1992).<\/p>\n\n\n\n

S.K. Bhatia, J.J. Hickman<\/strong> and F.S. Ligler, \u201cA New Approach to Engineering Patterned Biomolecular Assemblies,\u201d J. Am. Chem. Soc.<\/em> 114:4432 (1992).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, P.E. Laibinis, D.I. Auerbach, C. Zou, T.J. Gardner, G.M. Whitesides and M.S. Wrighton, \u201cToward Orthogonal Self-Assembly of Redox Active Molecules on Pt and Au: Selective Reaction of Disulfide with Au and Isonitrile with Pt,\u201d Langmuir<\/em> 8:357 (1992).<\/p>\n\n\n\n

J.J. Hickman<\/strong> and M.S. Wrighton, \u201cFace-Specific Interactions of Anionic Sulfur Donors with Oriented Crystals of (0001) CdX (X = Se, S) and Correlation with Electrochemical Properties,\u201d J. Am. Chem. Soc.<\/em> 113:4440 (1991).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, D. Ofer, P.E. Laibinis, G.M. Whitesides and M.S. Wrighton, \u201cMolecular Self-Assembly of Two-Terminal, Voltammetric Microsensors With Internal References,\u201d Science<\/em> 252:688 (1991).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, D. Ofer, C. Zou, M.S. Wrighton, P.E. Laibinis and G.M. Whitesides, \u201cSelective Functionalization of Gold Microstructures with Ferrocenyl Derivatives via Reaction With Thiols or Disulfides: Characterization by Electrochemistry and Auger Electron Spectroscopy,\u201d J. Am. Chem. Soc.<\/em> 113:1128 (1991).<\/p>\n\n\n\n

P.E. Laibinis, J.J. Hickman<\/strong>, M.S. Wrighton and G.M. Whitesides, \u201cOrthogonal Systems for Self-Assembled Monolayers: Alkanethiols on Gold and Alkane Carboxylic Acids on Alumina,\u201d Science<\/em> 245:845 (1989).<\/p>\n\n\n\n

J.J. Hickman<\/strong>, C. Zou, D. Ofer, P.D. Harvey, M.S. Wrighton, P.E. Laibinis, C.D. Bain and G.M. Whitesides, \u201cCombining Spontaneous Molecular Assembly with Microfabrication to Pattern Surfaces: Selective Binding of Isonitriles to Platinum Microwires and Characterization by Electrochemistry and Surface Spectroscopy,\u201d J. Am. Chem. Soc.<\/em> 111:7271 (1989).<\/p>\n","protected":false},"excerpt":{"rendered":"Jump to: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Pre-2004 See also: References 2025 Autar K, Guo X, Powell H, Patel A, Malik M, Grillo M, Akanda N, Narasimhan NS, Bogen W, Long C, Ammar RM, Hickman J. Developing a functional…","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-62","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - Hickman Hybrid Systems Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nanoscience.ucf.edu\/hickman\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Hickman Hybrid Systems Lab\" \/>\n<meta property=\"og:description\" content=\"Jump to: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Pre-2004 See also: References 2025 Autar K, Guo X, Powell H, Patel A, Malik M, Grillo M, Akanda N, Narasimhan NS, Bogen W, Long C, Ammar RM, Hickman J. 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