Research 1: R1-101A
Optimization of drug solubility and reproducible bioavailability are recognized as one of the major challenges in oral delivery of highly growing poorly soluble drugs (PSDs, estimated ≈ 75%) candidates. Advance technology, such as self-nanoemulsifying drug delivery systems (SNEDDS) using lipid excipients, bioactive materials and their conversion techniques (through Fluid bed coating, 3D Printing, etc.) have generated significant attention and gained high priority in recent years for their key roles in the delivery of PSDs. Bioactive oils of natural origin have gained huge interests from health care professionals and patients. The initial key achievement of these formulation systems is to increase the solubilization of the PSDs by the formation of stable nanoemulsions, and micellar systems. The current presentation aims to demonstrate factors which influence the design of successful self-nanoemulsifying lipid formulations in dosage form (including technology conversion) and affect the fate of the PSDs in GI tract after oral administration. The investigational research within the scope also provide additional information regarding current practice of lipid formulations with a particular emphasis on SNEDDS technology platforms, the opportunities/issues, challenges in both in vitro and in vivo conditions.
Biography: Dr. Mohsin Kazi is a Professor at the College of Pharmacy, King Saud University in Saudi Arabia. With a strong academic and industry background, he has made significant contributions to pharmacy through his research in advanced drug delivery systems. Prior to joining King Saud University, he served as a post-doctoral research fellow at Monash University in Australia and gained industry experience at Abbott Laboratories in Chicago, USA. Dr. Kazi holds a Bachelor of Pharmacy with Honors (B. Pharm Hons), a PhD in Pharmacy, Graduate Diploma in research commercialization from Monash University, and an MBA from Victoria University, Australia. His research expertise includes oral lipid-based nanoformulation systems, drug absorption of poorly-soluble drugs, conversion of liquid medications to solid dosage forms, and FDM 3D printing in pharmaceuticals. With over 130 scientific publications, he continues to inspire and educate future pharmacists while advancing pharmaceutical sciences.
Mohsin Kazi, Ph.D.
Department of Pharmaceutics
College of Pharmacy
King Saud University
Riyadh, Saudi Arabia
Ellen Kang, Ph.D. NanoScience Technology Center Ellen.Kang@ucf.edu